Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children.
PMID: 21468263
2011
Journal of Korean medical science
Abstract: The precore (G1896A) and core promoter (A1762T, G1764A) mutations of the hepatitis B virus gene are known to be associated with changes in immunologic phase or the progression to complicated liver disease in adults.
Introduction: Precore mutations, such as G1896A (guanine-to-adenine mutation at nucleotide 1,896), and core promoter (CP) mutations, including A1762T (adenine-to-thymine mutation at nucleotide 1,762) and G1764A (guanine-to-adenine mutation at nucleotide 1,764), are known to be associated with HBeAg stat
Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection.
PMID: 21490166
2011
Clinical and vaccine immunology
Abstract: The hepatitis B virus (HBV) PreS mutations C1653T, T1753V, and A1762T/G1764A were reported as a strong risk factor of hepatocellular carcinoma (HCC) in a meta-analysis.
Full genome characterization of hepatitis B virus strains from blood donors in Iran.
Abstract: The double mutations A1762T/G1764A and G1764T/C1766G were found in 20.7% and 24.1% of the strains, respectively.
Ultrasensitive quantification of hepatitis B virus A1762T/G1764A mutant by a SimpleProbe PCR using a wild-type-selective PCR blocker and a primer-blocker-probe partial-overlap approach.
PMID: 21562108
2011
Journal of clinical microbiology
Abstract: Hepatitis B virus (HBV) carrying the A1762T/G1764A double mutation in the basal core promoter (BCP) region is associated with HBe antigen seroconversion and increased risk of liver cirrhosis and hepatocellular carcinoma (HCC).
A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients.
Introduction: G1896A variation was mainly present in patients who were HBeAg-negative natives of Asian or Mediterranean basin, whereas A1762T/G1764A dual variations were detected in a similar proportion of HBeAg-negative and HBeAg-positive patients.
Introduction: In addition to genotype B, G1896A variation, not A1762T/G1764A dual variations, is proposed to be another major mechanism to explain spontaneous HBeAg loss in the natural history of chronic HBV infection.
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.
Abstract: The precore/core frame A1762T and G1764A double mutation was detected before treatment and remaining in this condition during the entire follow-up.
Conclusion: The HBV genomic characterization at preC-C level showed the presence of A1762T and G1764A double mutation that was early detected when the patient was untreated, remaining in this condition during the entire follow-up.
Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.
Abstract: METHODS: We constructed a series of HBx mutants with changes in the CP region that correspond to A1762T/G1764A (TA), T1753A, T1768A, or a combination of these (combo) and expressed them, along with wild-type HBx under control of its endogenous promoter, in primary human hepatocytes (PHHs) and HepG2 cells.
Introduction: Clinical studies have shown that the common double mutation A1762T/G1764A (TA) in the HBV basal core promoter (CP) region is independently associated with HCC.
Discussion: Our results in He
Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure.
Abstract: In conclusion, CHB patients with genotype B, G1896A, and A1762T/G1764A had a higher tendency to develop liver failure than patients with genotype C.
Abstract: In genotype B patients, the A1762T/G1764A, A1846T, and G1896A mutations were significantly more prevalent in patients with acute-on-chronic liver failure than CHB (50.7% vs.
Abstract: In multivariate analysis, the risk factors for acute-on-chronic liver failure were genotype B, A1762T/ PMID: 21775451
2011
Journal of virology
Abstract: The A1762T/G1764A core promoter mutations were prevalent in genotype C isolates and correlated with increased replication capacity, while the A1752G/T mutation frequently found in genotype B isolates correlated with a low replication capacity.
Abstract: We propose that the low intracellular levels of viral DNA and core protein of wild-type genotype C delay immune clearance and trigger the subsequent emergence of A1762T/G1764A core promoter mutations to upregulate replication; efficient virion secretion compensates for the low replication capacity to ensure the establishment of persistent infection by genotype C.
Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years.
PMID: 21785721
2011
Hepatitis research and treatment
Result: A1762T/G1764A double mutation existed in all clones, and G1896A existed in 4 clones obtained from all time points.
Discussion: In the present study, all clones of the mother from three time points had double mutations of nucleotide A1762T/G1764A in basal core promoter (BCP), four of which were also coupled with G1896A.
Discussion: Other mutations such as C934A, C2351T/A2353T, C2444T, A1762T/G1764A, and G1896A were scattered in the whol
HBV mutation literature information.
PMID: 
2011
Journal of Korean medical science
Browser Board
Co-occurred Entities
Filtrator
ViMRT