Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion.
PMID: 25593470
2015
World journal of gastroenterology
Abstract: METHODS: The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface antigen (HBsAg), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBeAg seroconversion (n = 25), in those who were persistently HBeAg positive (n = 18), and in those who were persistently anti-HBe positive (n = 43).
Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contribute to Hepatocarcinogenesis by Deregulating Skp2 and P53.
PMID: 25567052
2015
Digestive diseases and sciences
Abstract: METHODS: A HBx combination (combo) mutant with changes in the CP region that corresponded to A1762T/G1764A (TA), T1753A, and T1768A was constructed and expressed in L-02 and Hep3B cells.
Clinical significance of hepatitis B virus precore and core promoter variants in Korean patients with chronic hepatitis B.
PMID: 24406435
2015
Journal of clinical gastroenterology
Abstract: METHODS: We assessed serum HBeAg, HBV DNA levels, alanine transferase (ALT) levels, and progression of liver fibrosis in 226 Korean CHB patients, presumed to be infected with genotype C HBV, to analyze HBV variants in the preC region (G1896A) and CP regions (A1762T, G1764A).
Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.
Abstract: BACKGROUND AND OBJECTIVE: Precore (PC) variant (G1896A) and basal core promoter (BCP) variant (A1762T/G1764A) of HBV are associated with risk of hepatocellular carcinoma in HBV carriers.
Occult hepatitis B virus infection with positive hepatitis B e antigen.
PMID: 25218700
2015
Clinica chimica acta; international journal of clinical chemistry
Abstract: The HBV had double mutations (A1762T and G1764A) in the basal core promoter but had no mutation in the pre C/C gene in both patients.
Correlation between the promoter basal core and precore mutations and HBsAg quantification in French blood donors infected with hepatitis B virus.
Abstract: In HBV-GN patients, missense nucleotide mutations of C1653T, A1726C, A1727T, C1730G, T1753C, A1762T, and G1764A were detected in 84% of subjects, all located in the trans-acting regulatory region of the X gene.
Variability in the precore and core promoter region of the hepatitis B virus genome.
Abstract: The study confirmed that core promoter and precore mutations occur at key positions (A1762T, G1764A, G1896A, and G1899A), and that the proportions of strains with seroconvertion in patients differ between the four HBV genotypes.
Genetic variability of hepatitis B and C viruses in Brazilian patients with and without hepatocellular carcinoma.
Abstract: Core promoter T1753V, A1762T, and G1764A mutations were more frequent in patients with HCC than in those without, although with no statistical difference.
Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.
Abstract: Accumulation of eight key mutations located in the X/preC regions of the hepatitis B virus (HBV) genome (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) is a risk marker for the development of hepatocellular carcinoma (HCC).
Abstract: Analyses were focused on patient >=40 years of age infected by HBV genotype C with A1762T and G1764A mutations in the basal core promoter region (<
HBV mutation literature information.
PMID: 
2015
World journal of gastroenterology
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