Conclusion: Interestingly, the G1896A and A1762T/G1764A mutations, although associated with fulminant hepatitis B development in other studies, were found at low frequency in ACLF patients compared to non-ACLF/HBeAg negative hepatitis CHB patients.
Figure: a The incidence of A1762T/G1764A dual mutations was significantly higher in HBeAg negative hepatitis group than in both HBeAg positive (****p < 0.0001) and HBeAg negative ACLF-CHB groups (****p < 0.0001) and immun
Patients with Coexistence of Circulating Hepatitis B Surface Antigen and Its Antibody May Have a Strong Predisposition to Virus Reactivation During Immunosuppressive Therapy: A Hypothesis.
Abstract: DNA sequencing analysis of the HBV genome revealed triple mutations (A1762T, G1764A, and T1753V) in the BCP region, which could further enhance the ability of HBV replication.
Abstract: Recent studies have shown that the uncommon serological pattern of coexistent circulating HBV surface antigen (HBsAg) and its antibody (anti-HBs) was associated with double mutations (A1762T/G1764A) in the basal core promoter (BCP) region of the HBV genome, which is critical for HBV replication.
Introduction: Coexistence of circulating HBsAg and anti-
Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region.
Introduction: For example, high serum or intrahepatic HBV-DNA levels and the presence of basal core promoter A1762T/G1764A mutation can independently predict outcomes of long-term chronic HBV infection as well as postoperative survival in HCC.
Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naive patients.
Result: However, we found that the medium/low MBL2 group has higher mutation rate in T1653, T1674, T1753, A1726T and G1764A when being compared with high MBL2 group, and significance was observed (Table 3 and Figure 2).
Table: G1764A
HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression.
Abstract: Results showed double mutation A1762T/G1764A (TA) combined with other mutation(s) (TACO) in HBV genome and phosphorylated AKT (pAKT) were more common in PHCC than BHCC.
Introduction: The double mutation A1762T/G1764A (TA) in the HBV basal core promoter (CP) region has been widely recognized to be independently associated with HCC.
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Discussion: After adjustment for age, history of cigarette smoking and alcohol consumption, unconditional logistic regression analyses showed that pre-S deletion, C1653T, A1762T/G1764A, A2159G, A2189Y, G2203W, and C2288R mutations were significantly associated with high HCC risk.
Discussion: Meanwhile, the carcinogenic risk of pre-S deletion and pre-S2 start codon mutation in pre-S gene, C1653T, and A1762T/G1764A mutations in
HBx mutations promote hepatoma cell migration through the Wnt/beta-catenin signaling pathway.
Abstract: HBx mutations (T1753V, A1762T, G1764A, and T1768A) are frequently observed in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Abstract: Additionally, mutations were more common in early stages of liver disease in HBV subgenotype F2-infected patients, and a significant association between this subgenotype and the emergence of T 1753C, A1762T, A1762T/G1764A (p=0.04) and C1773T (p=0.001) mutations in chronic patients was found, when compared to the HBV subgenotype F3.
Abstract: By comparing F2 with all other HBV subgenotypes, a positive association for the three basal core promoter (BCP) mutants (A1762T, A1762T/G1764A p=0.01, G1764A p=0.04) was found.
HBV mutation literature information.
PMID: 
2017
Virology journal
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