Abstract: RESULTS: Higher HBV DNA levels, subgenotype B1/Bj, A1762T/G1764A, G1896A, G1899A and A2339G mutation were significantly more frequent (P < 0.05), while hepatitis B e-antigen was less frequent in the FH-T patients than AHB.
[Analysis of the relevance of the mutations of the precore and basic core promoter in HBV genome with the DNA amount of HBV viremia].
PMID: 19489434
2009
Rinsho byori. The Japanese journal of clinical pathology
Abstract: We assessed the association of continuous viremia with the precore (PC) (G1896A) mutation, basic core promoter (BCP) (A1762T, G1764A) mutations, the viral genotype and the quantity of viral DNA.
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
Abstract: C1653T, T1753V, and A1762T/G1764A were more strongly associated with an increased risk of HCC in hepatitis B e antigen (HBeAg)-positive subjects than in HBeAg-negative subjects.
Abstract: PreS mutations were more strongly associated with an increased risk of Abstract: CONCLUSIONS: HBV PreS mutations, C1653T, T1753V, and A1762T/G1764A are associated with an increased risk of HCC.
First report of genotype e of hepatitis B virus in an Indian population.
Abstract: A1762T/G1764A mutation was observed in 1.96% and 5.36%, whereas T1753V mutation was found in 2.94% and 1.79% of HBV/B and HBV/C, respectively.
Result: Double mutation (A1762T/G1764A), one of significant mutations associated with advanced liver disease including HCC, was only found in 1.96% (2/102) of HBV/B.
Discussion: Double mutation (A1762T/G1764A) was only found in 1.96% of HBV/B.
Discussion: In our previous study, we included 15 HBV-associated liver disease samples from Makassar, and found that the prevalence of T1753V and <
Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia.
PMID: 19705499
2009
World journal of gastroenterology
Abstract: Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease.
Abstract: Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease.
Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis.
Abstract: The pBFH2 construct with A1762T/G1764A, G1862T, and G1896A showed the largest amount of core particle-associated intracellular HBV DNA, but no significant increase of extracellular HBV DNA in comparison with the wild construct, suggesting that these mutations might work together for retention of the replicative intermediates in the cells.
Clinical relevance and public health significance of hepatitis B virus genomic variations.
PMID: 19998495
2009
World journal of gastroenterology
Abstract: PreS deletions, C1653T, T1753V, and A1762T/G1764A are associated with an increased risk of HCC.
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
HBV mutation literature information.
PMID: 
2009
Hepatology research
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