literature

A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.

PMID: 21063480 2010 Hepatology international

Abstract: By multiple logistic regression analysis, the presence of cirrhosis, A1762T/G1764A and G1899A mutations were independently associated with the risk of HCC.

Abstract: CONCLUSION: These data suggested that A1762T/G1764A and G1899A mutations were associated with the development of HCC in Thai patients.

Abstract: RESULTS: The prevalence of T1753C/A, A1762T/G1764A and G1899A mutations were significantly higher in the

Abstract: A1762T/G1764A double mutation rate was 40.0% (18/45), 84.4% (38/45), 73.5% (36/49) and 92.6% (25/27) respectively in different groups.

Abstract: CONCLUSION: A1762T/G1764A double mutation has a close relationship with the progress of HBV-infection diseases, but is not specific to patients with ACLF.

Abstract: HBV DNA level (log) of patients with A1762T/G1764A double mutation was 5.68 +/- 1.36, lower than but having no significant statistic difference compared to patients without the double mutation (6.14 +/- 1.81, P = 0.075).

The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis.

PMID: 19070921 2009 Journal of hepatology

Abstract: BACKGROUND/AIMS: Although there have been a few reports regarding the effect of basal core promoter (BCP) double mutations (A1762T and G1764A) on hepatitis B viral loads, the association remains uncertain.

Introduction: One of the most critical changes is the appearance of double mutations at nt 1762 (A-T) and 1764 (G-A) in the BCP.

Association between genomic heterogeneity of hepatitis B virus and intrauterine infection.

PMID: 19272629 2009 Virology

Abstract: Particularly, A1762T/G1764A mutations seemed to be disadvantageous for fetal infection.

Prevalence of basal core promoter and precore mutations in Chinese chronic hepatitis B patients and correlation with serum HBeAG titers.

PMID: 19319958 2009 Journal of medical virology

Abstract: The A1762T and G1764A mutations in the basal core promoter (BCP) region and the G1896A mutation in the precore (PC) region of hepatitis B virus (HBV) genome are found commonly in HBeAg-negative patients.

Introduction: The most common BCP mutations are A to T at nt 1762 and G to A at nt 1764 (T1762/A1764).

Discussion: These HBeAg positive patients of genotype C infection also had a higher prevalence of the A1762T/G1764A

Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.

PMID: 19327810 2009 Virology

Discussion: The high replication capacity was mapped to nucleotides 1574-1986, where 7 core promoter mutations are present: G1751T, T1753A, G1757A, A1762T, G1764A, C1766T, and T1768A.

Discussion: The most common core promoter mutations, A1762T/G1764A, had been found by other investigators to moderately increase genome replication.

Discussion: Thus, clone 4B contains a combination of T1753C, A1762T, G1764A, and C1766T mutat

Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes.

PMID: 19382250 2009 Journal of medical virology

Abstract: Of the 17 patients, 3 carried both pre-C (G1896A) and BCP (A1762T/G1764A) mutants, 1 pre-C only and 1 BCP only.

Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels.

PMID: 19430095 2009 Antiviral therapy

Abstract: RESULTS: The frequency of patients with detectable PC stop codon mutation (G1896A), basal core promoter mutation (A1762T/G1764A) and pre-S deletion at baseline was 22.4%, 21.6% and 12.1%, respectively.

A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.

PMID: 19431214 2009 International journal of cancer

Abstract: Compared with the HBsAg-positive HCC controls, occult HBV-infected HCC patients had higher frequencies of M1I and Q2K in pre-S2 gene, G185R and S210N in surface gene, A36T and A44L in X gene, and G1721A in enhancer II gene, and had lower rates of pre-S deletions and A1762T/G1764A,

PMID: 19439550 2009 The Journal of general virology

Abstract: During chronic hepatitis B virus (HBV) infection, double substitution mutations in the basal core promoter (BCP) region frequently emerge that include A1762T/G1764A and the neighbouring C1766T/T1768A mutations, here termed BCP1 and BCP2, respectively.