Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Result: All the high replicating clones harbored A1762T/ G1764A mutations, and all but the three non-HCC clones harbored G1896A precore mutation.
Result: Consistent with the high prevalence of core promoter mutations in genotype C, especially at the advanced stages of liver diseases, 34 of the 36 clones (including all the 20 HCC-derived clones) harbored the A1762T/G1764A double mutation.
Result: Finally, the only two clones lacking A1762T/G1764A mutations (12.1 and 12.3 from a non-
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
5Result: Fifteen (43%) had the double A1762T/G1764A mutation (""TA mutation"") in the BCP region; an additional patient had only G1764A."
8Discussion: The double A1762T/G1764A (""TA"" mutation) in the BCP region affects mRNA transcription and decreases HBeAg production.
Abstract: We identified BCP A1762T/G1764A in 15/35 (43%), PC G1896A in 20/35 (57%), 'a' determinant mutations in 12/45 (26.7%) and preS2 deletions in 6/16 (37.5%).
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
Abstract: A meta-analysis of pooled results from case-control studies examined the association between mutations G1896A, A1762T, G1764A, and A1762T/G1764A and the risk of HCC.
Abstract: CONCLUSION: In summary, we found that G1896A, A1762T, G1764A, and A1762T/G1764A are associated with an increased risk of HCC.
Abstract: RESULTS: We included 29 articles for analysis and found that G1896A (summary odds ratios [OR] = 2.04, 95% confidence interval [CI] = 1.41-2.95), Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
PMID: 28606415
2017
The Brazilian journal of infectious diseases
Abstract: A total of 49 patients with chronic hepatitis B were included in the study, and the HBV A1762T/G1764A double mutant strain was detected in four samples (8.16%) by polymerase chain reaction followed by restriction fragment length analysis (PCR-RFLP).
Abstract: In this study, 75% of the samples with the HBV A1762T/G1764A double mutation were HBeAg negative and anti-HBe positive, reflecting seroconversion even though they still displayed high viral loads.
Abstract: Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing
Clustering infection of hepatitis B virus genotype B4 among residents in Vietnam, and its genomic characters both intra- and extra-family.
Result: There were no C1653T mutations, two (4.5%) T1753V mutations, five (11.4%) double mutations of A1762T/G1764A, and three (6.8%) double mutations of C1766T/T1768A.
Discussion: But looking at the promoter region mutations, G1613A mutation was identified in 10.3% of these 31 strains, C1653T was 0%, T1753V was 3.2%, A1762T/G1764A was 16.1%, and C1766T /T1768A was 3.2%.
Discussion: Reported promoter mutations are G1613A, C1653T, and
Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants.
PMID: 28774406
2017
Best practice & research. Clinical gastroenterology
Abstract: In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B.
Molecular characterization of hepatitis B virus in Vietnam.
Result: T1753C, G1757A, A1762T, G1764A and C1766G mutations were identified in 11.1% (5/135), 7.4% (10/137), 25.9%% (35/135), 24.4% (33.135) and 2.2% (3/135) of the isolates and A1762T and G1764 T mutations were significantly more frequent in the genotype C1 isolates (p < 0.001) (Table 3).
Result: A double mutation (A1762T and G1764A) was identified in 67.5% (25/37) of the C1 subgenotype isolates compared to 8.2% (8/98) of the genotype B isolates (p < 0.001).
Table: G1764A
Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.
Result: We found that the presence of a double core promoter mutation (A1762T and G1764A) correlated with the development of HCC, as reported previously (data not shown).
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
PMID: 28902288
2017
Memorias do Instituto Oswaldo Cruz
Result: HCC and cirrhosis were found to be associated with the presence of the A1762T/G1764A mutant (OR = 5.42
Result: An association between infection with the HBV A1762T/G1764A BCP mutant and the presence of moderate and severe fibrosis, clinically detected hepatic cirrhosis, and the presence of HCC was verified in this study.
Result: HBV strains with BCP mutations, the most frequent being the A1762T/G1764A double mutation, were detected in 59.3% (70/118) of the patients studied.
HBV mutation literature information.
PMID: 
2017
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