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 HBV mutation literature information.


  Effect of basal core promoter and pre-core mutations on hepatitis B virus replication.
 PMID: 18343830       2008       The Journal of general virology
Abstract: Substitutions A1762T/G1764A and T1753C, C1766T and T1768A in the BCP region, and G1896A and G1899A in the pre-C region, were examined either alone or in combination, using a common genetic background.
Abstract: The double BCP mutation (A1762T/G1764A) and the pre-C mutations (G1896A, G1899A), either alone or in combination, had no appreciable effect on the replication capacity of the virus.


  Detection of HBV core promoter and precore mutations helps distinguish flares of chronic hepatitis from acute hepatitis B.
 PMID: 18410611       2008       Journal of gastroenterology and hepatology
Abstract: RESULTS: Mutations in the core promoter (A1762T/G1764A) and precore region (G1896A) were more frequent in patients with acute exacerbation of chronic hepatitis than acute hepatitis (81% vs 19%; P < 0.0001 and 58% vs 6%; P < 0.0001, respectively).


  Analysis of the entire nucleotide sequence of hepatitis B causing consecutive cases of fatal fulminant hepatitis in Miyagi Prefecture Japan.
 PMID: 18428142       2008       Journal of medical virology
Abstract: As for the nucleotides sequences of them, previously reported mutations of G1896A, A1762T, and G1764A were present.


  Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease.
 PMID: 18507754       2008       Journal of viral hepatitis
Abstract: The double mutation A1762T-G1764A was more prevalent in patients with advanced liver disease (AdLD) and was associated with higher alanine aminotransferase and viral load.
Abstract: The results indicate that in genotype D CHB, the presence of the A1762T-G1764A mutation was associated with more aggressive liver disease while the G1757A substitution was associated with protection from advanced disease.


  Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.
 PMID: 18508941       2008       Journal of clinical microbiology
Abstract: Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC.


  Molecular characterization of hepatitis B virus (HBV) isolates, including identification of a novel recombinant, in patients with acute HBV infection attending an Irish hospital.
 PMID: 18649329       2008       Journal of medical virology
Abstract: A triple mutation, T1753C/A1762T/G1764A was identified in only one isolate (Irish-3) associated with severe infection.


  Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
 PMID: 18675784       2008       Biochemical and biophysical research communications
Abstract: A1762T and G1764A mutations in the basal core promoter are often present in HBV patients but seldom in asymptomatic carriers, and are highly correlated with the increased risk of HBV-associated hepatocellular carcinoma (HCC).
Abstract: We also show that T1762A and G1764A double mutations synergize the reduction of the promoter activity.


  Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma.
 PMID: 18695135       2008       Journal of the National Cancer Institute
Abstract: Among participants with a baseline HBV DNA level of at least 10(4) copies/mL, HCC incidence per 100 000 person-years was higher for those with the precore G1896 (wild-type) variant than for those with the G1896A variant (955.5 [95% CI = 749.0 to 1201.4] vs 269.4 [95% CI = 172.6 to 400.9]) and for those with the BCP A1762T/G1764A double mutant than for those with BCP A1762/G1764 (wild-type) variant (1149.2 [95% CI = 872.6 to 1485.6] vs 358.7 [95% CI = 255.1 to 490.4]).
Abstract: Participants who had a baseline serum HBV DNA level greater than 10(4) copies/mL (n = 1526) were tested for the precore G1896A and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
 PMID: 18844615       2008       The American journal of gastroenterology
Introduction: The common precore mutation (G1896A), mutations in enhancer II (C1653T) and the basal core promoter (T1753V and the double mutations, A1762T, G1764A), and deletions in the pre-S region have been reported to be associated with the development of HCC.
Result: Almost all mutations at nt 1653 and nt 1753 are co-incident with the A1762T, G1764A mutations.
Result: Of the 2998 recruited initially, 740 were excluded: 638 because the BCP sequences could not be determined at baselin


  Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient.
 PMID: 19008175       2008       European journal of medical research
Abstract: Because of unchanged VL sequence analysis was performed three months later, which showed the mutation (rtS219A) and the concomitant mutation (sS210R) and 2 mutations in core promoter region (A1762T), (G1764A).



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