HBV mutation literature information.


  The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes.
 PMID: 30600290       2018       Annals of hepatology
1Abstract: Further study indicated that interactions between ICOS rs10932029 genotype ""TC"" and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group."
1Abstract: The interactions between the rs10932029 genotype ""TC"" and A1762T or A1762T/G1764A mutations could decrease the risk of LC."
Abstract: Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group.


  BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients.
 PMID: 29948380       2018       Archives of virology
Abstract: A1762T, G1764A and G1896A mutations were common mutations identified in the BCP/PC region.


  The association between hepatitis B mutants and hepatocellular carcinoma: A meta-analysis.
 PMID: 28489767       2017       Medicine
Abstract: A meta-analysis of pooled results from case-control studies examined the association between mutations G1896A, A1762T, G1764A, and A1762T/G1764A and the risk of HCC.
Abstract: CONCLUSION: In summary, we found that G1896A, A1762T, G1764A, and A1762T/G1764A are associated with an increased risk of HCC.
Abstract: RESULTS: We included 29 articles for analysis and found that G1896A (summary odds ratios [OR] = 2.04, 95% confidence interval [CI] = 1.41-2.95),  PMID: 27328656       2017       Journal of medical virology
Abstract: Difference in basal core promoter A1762T/G1764A mutations and precore G1896A mutation incidences was not significant between B/C recombinant and genotypes B or C virus, although the significance was there between genotypes B and C viruses.


  Hepatitis B virus infection in children of HBV-related chronic liver disease patients: a study of intra-familial HBV transmission.
 PMID: 27624502       2017       Hepatology international
Abstract: Recognized mutations associated with HBsAg detection and/or vaccination failure, T140I, T143S/M, G145R, and Y161F, were identified in 20 subjects; while mutations linked to HBeAg-defective variants, PC G1896A and BCP A1762T/G1764A, were found in 7 and 11 subjects, respectively.


  Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
 PMID: 27650283       2017       Journal of hepatology
Discussion: Indeed, Yan et al, reported that HBV BCP A1762T/G1764A mutations might be associated with low HBsAg levels, and Pollicino et al.


  Identification of a new hepatitis B virus recombinant D2/D3 in the city of Sao Paulo, Brazil.
 PMID: 27787680       2017       Archives of virology
Abstract: The precore/core mutations A1762T + G1764A (40.9%) were found mostly in genotypes A and D, and G1896A (29.55%) was more frequent in genotype D than in genotype A.


  A novel hepatitis B virus subgenotype D10 circulating in Ethiopia.
 PMID: 27808472       2017       Journal of viral hepatitis
Abstract: In addition, 63% genotype A and 33% genotype D strains had the basal core promoter mutations, A1762T/G1764A.


  The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.
 PMID: 28088502       2017       Infection, genetics and evolution
Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.


  Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
 PMID: 28325923       2017       Emerging microbes & infections
Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.



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