Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Conclusion: Furthermore, the present data indicate a high rate of G1896A mutant in the PC region among Iranian CHB patients and a negative correlation between the emergence of A1762T/G1764A mutation and G1764T/C1766G mutant in the BCP region.
Result:
Result: A1762T and G1764A were frequently detected together in 23.0% (6/26) of the isolates.
Result: However, none of the patients with A1762T/G1764A mutation carried the G1764T/C1766G mutant (Table 2).
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Abstract: The C1505A mutation in X region, T1753V and A1762T/G1764A mutations in the basal core promoter region and C1858T in precore (PC) region were frequent and only detected in patients with ALD (28.9, 40, 73.5 and 17.6%, respectively), whereas the G1896A mutation in the PC region was frequently detected in HBV carriers.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Introduction: Double mutations, A1762T and G1764A, in the basic core promoter region result in decreased HBeAg expression and enhanced viral genome replication; these mutations are frequently found in HBeAg-negative chronic hepatitis patients.
Discussion: The A1762T and G1764A mutations in the basic core promoter region are associated with an increased risk of HCC in genotype C patients.
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.
Discussion: Taken together, these results provide a potential mechanism whereby HBV encoding X_K130M/V131I (BCP_A1762T/G1764A) may contribute to the high rate of HCC observed clinically in patient cohorts containing these mutations.
Discussion: The X_K130M/V131I amino acid changes are encoded by nucleotide changes at BCP_A1762T/G1764A, which also result in a decrease in PC/C mRNA and subsequent HBeAg expression.
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Introduction: For instance, it was found that A1762T/G1764A were novel mutations within CP and could lead to decreased HBeAg expression but enhanced viral replication, which correlated with liver disease severity.
Discussion: Whether single-site mutations may have such a significant effect on activity, we refer to the effects of the A1762T/G1764A mutation in HBV.
Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b.
Abstract: In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Introduction: The A1762T/G1764A BCP double mutation was associated with a hazard ratio (HR) of 1.73 for developing HCC.
Introduction: The most frequent BCP mutation is a double mutation involving an A to T substitution at nucleotide 1762 and a G to A substitution at nucleotide 1764.
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, PMID: 29096158
2018
Virology
Abstract: The BCPdm (A1762T/G1764A) and preCore (G1896A) mutants induced higher levels of apoptosis than the wt virus.
HBV mutation literature information.
PMID: 
2019
Mediterranean journal of hematology and infectious diseases
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