Result: The A1762T and G1764A mutations were found in two cases.
Table: G1764A
Discussion: Typically, BCP mutations (A1762T and G1764A) can reduce the mRNA synthesis of the pre-C region, which is reflected as a very low level of HBV DNA.
Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Abstract: APOBECs-related HBV mutations, including G1764A, were more frequent in the sera than in the adjacent tissues.
Abstract: HBV QC and A1762T/G1764A in the sera and tumors have contrary prognostic effects in HCC.
Abstract: High-frequent A1762T/G1764A in the sera predicted an unfavorable RFS (P < 0.001), whereas, in the tumors, it predicted a favorable RFS (P = 0.035).
Hepatitis B virus genome diversity in adolescents: Tenofovir disoproxil fumarate treatment effect and HBeAg serocon version.
Abstract: The basal core promoter (BCP) variants, A1762T and G1764A, and the pC variant, G1896A, were most often enriched at or after seroconversion.
Impacts of the Percentage of Basal Core Promoter Mutation on the Progression of Liver Fibrosis After Hepatitis B e Antigen Seroconversion.
PMID: 32860707
2021
The Journal of infectious diseases
Abstract: CONCLUSIONS: The percentage of A1762T/G1764A mutations after HBeAg seroconversion was associated with liver fibrosis.
Abstract: Hepatitis B e antigen seroconversion age is positively correlated with the percentages of A1762T/G1764A mutation at inflammatory phase before HBeAg seroconversion.
Abstract: RESULTS: We demonstrated that the percentages of A1762T/G1764A mutation are significantly higher in subjects with an LSM >7 kPa than in those with an LSM <=7 kPa after HBeAg seroconversion.
Abstract: Subjects who underwent interferon, entecavir, or tenofovir disoproxil
Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.
Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Abstract: Calculation of the pgRNA secondary structure suggests a destabilization of the pgRNA structure by A1762T/G1764A that was compensated by GCAC1809-1812TTCT.
Abstract: GCAC1809-1812TTCT was strongly associated with coexistence of basal core promoter (BCP) double mutation A1762T/G1764A and lower HBV DNA levels.
Introduction: For example, the double mutation A1762T/G1764A is the most common mutation in BCP and was found in some studies to be associated with progression to advanced liver disease and HCC development.
Introduction: However, altho
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
Abstract: HBV variants, particularly the G1896A pre-core (PC) and A1762T/G1764A basal core promoter (BCP) mutations, are established risk factors for cirrhosis and HCC, but the molecular biological basis is unclear.
Abstract: RESULTS: HBeAg expression was reduced in PC and BCP variants, and higher supernatant HBV DNA and HBV RNA levels were found with A1762T/G1764A vs. G1896A mutant (p_< 0.05).
Figure: HepG2 cells were co-transfected with pcDNA-GFP +/- linearized wild-type (WT),
The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.
Abstract: rs3135395-T, rs477515-T and rs2395178-G were inversely associated with the generation of A1762T/G1764A, T1753V and C1653T, the HCC-risk HBV mutations.
[Relationship between mutations of HBV basal core promoter region in HBsAg-positive mothers and intrauterine transmission].
PMID: 32564557
2020
Zhonghua liu xing bing xue za zhi
Abstract: Conclusion: A1762T/G1764A double mutations of HBV DNA from the genotype C of those HBsAg-positive mothers could reduced the risk of HBV intrauterine transmission during pregnancy.
Abstract: Maternal A1762T/G1764A double mutations appeared to be possibly associated with neonatal HBeAg (P=0.050).
Abstract: Rates of A1762T/G1764A double mutations were significantly different between the intrauterine transmission group and the control group (7.53% vs.
Abstract: Results from the multivariate analysis showed that the A1762T/G1764A double mutations had reduced the risk of intrauterine transmission (aOR=0.065, 95%CI:
Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Result: In the level of nucleotide, the double mutations A1762T/G1764A in the BCP region of HBV (nt1742-1849) were frequently observed in HBV/CD sequences (50/179, 27.9%).
Table: G1764A
Discussion: In this study, the A1762T/G1764A double mutations were observed in 27.93% in HBV CD recombinant sequences.
Discussion: Previous studies reported that A1762T/G1764A double mutation in BCP (nt.1742-1849) was the strongest viral factor associated with the development of liver disease.
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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