Result: The A1762T and G1764A mutations were found in two cases.
Table: G1764A
Discussion: Typically, BCP mutations (A1762T and G1764A) can reduce the mRNA synthesis of the pre-C region, which is reflected as a very low level of HBV DNA.
Transcriptome analysis of hepatoma cells transfected with Basal Core Promoter (BCP) and Pre-Core (PC) mutant hepatitis B virus full genome construct.
PMID: 33595430
2021
The Journal of general virology
Abstract: Infections with Basal Core Promoter (BCP) (A1762T/G1764A) and Pre-Core (PC) (G1896A) hepatitis B virus HBeAg mutants are associated with severe liver injury.
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection.
Result: In addition, among these patients, 16 were infected with HBV strain harbouring basic core promoter (BCP) mutation A1762T/G1764A, whereas the remaining 45 patients were infected with BCP wild-type strain.
Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Abstract: APOBECs-related HBV mutations, including G1764A, were more frequent in the sera than in the adjacent tissues.
Abstract: HBV QC and A1762T/G1764A in the sera and tumors have contrary prognostic effects in HCC.
Abstract: High-frequent A1762T/G1764A in the sera predicted an unfavorable RFS (P < 0.001), whereas, in the tumors, it predicted a favorable RFS (P = 0.035).
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
Abstract: HBV variants, particularly the G1896A pre-core (PC) and A1762T/G1764A basal core promoter (BCP) mutations, are established risk factors for cirrhosis and HCC, but the molecular biological basis is unclear.
Abstract: RESULTS: HBeAg expression was reduced in PC and BCP variants, and higher supernatant HBV DNA and HBV RNA levels were found with A1762T/G1764A vs. G1896A mutant (p_< 0.05).
Discussion: However, these in vivo findings are in contrast with our in vitro results in which secreted HBV
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Abstract: Calculation of the pgRNA secondary structure suggests a destabilization of the pgRNA structure by A1762T/G1764A that was compensated by GCAC1809-1812TTCT.
Abstract: GCAC1809-1812TTCT was strongly associated with coexistence of basal core promoter (BCP) double mutation A1762T/G1764A and lower HBV DNA levels.
Result: After the implementation of GCAC1809-1812TTCT in addition to A1762T/G1764A (Figure 5C), the RNA secondary structure was stabilized by a hairpin structure and the MFE decreased approximately to the WT level (-69.1 kcal/mol; GC content of 46%).
Result: Although this mutation was found in 66% (226 of 340) of the samples with A1762T/<
Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.
Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
Viral hepatitis B and C in HIV-exposed South African infants.
5Result: The ""Week 0"" Cape Town sample showed a similar serological profile to the ""Week 48"" sample from the same child and also had the double A1762T/G1764A BCP mutation."
Abstract: The Result: Both sequences harboured the double A1762T/G1764A BCP mutation.
Result: Sequence analysis revealed the M204I mutation in the reverse transcriptase domain of the polymerase gene in the Durban sample while the Cape Town sample harboured the double A1762T/G1764A BCP mutation in the core gene.
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.
Abstract: HCC-associated mutations were detected in 33.7% of the sequences, with significantly higher frequency of C1653T, T1753V and A1762T/G1764A in genotype G than C (P < 0.001).
Result: C1653T, T1753V and A1762T/G1764A were highly frequent in genotype G (95, 95, and 97.5%, respectively), followed by genotype C (12, 18.1, and 46.1%, respectively), while Pre-S deletions prevailed in genotype C (3.3%) (Table 1).
Result: Significant differences in A1762T/G1764A rates were found within genotypes B, C, D, and F, with subgenotypes B
Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
Abstract: Through application of deep whole-genome sequencing we typed the isolate as genotype-D1, and identified several minority variants including G1764A and G1986A substitutions in the pre-core promoter and pre-core regions, which support CHB-AR rather than AHB.
Conclusion: The most prevalent minority variant mutations in our HBV sequences were G1896A, G1899A and G1764A (precore/core and basal core promotor sequences respectively) ( Table 1).
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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