Comparative analysis of HBV basic core promoter/pre-core gene mutations and viral quasispecies diversity in HIV/HBV co-infected and HBV mono-infected patients.
Abstract: Among the patients infected with HBV genotype C and HBeAg-negative status, the frequency of A1762T/G1764A double mutations was significantly lower in HIV/HBV co-infected patients than in HBV mono-infected patients (53.3% vs.
Abstract: However, A1762T/G1764A double mutations did not differ in the other groups (P >0.05).
Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.
Result: T1753A, A1761C, and G1764A mutations caused the conversion of Ile Asn at amino acid 127 (I127N), Lys Gln at amino acid 130 (K130Q), and Val Leu at amino acid 131 (V131L) of the X protein, respectively (S3 Fig).
Result: Of these, T1753A and A1761C mutations were detected in one sample (HB55); and G1764T/A, C1766G/T, and C1773T mutations were detected in two samples (HB35 and HB55).
The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma.
Abstract: Wild-type HBx (WT-HBx) and four HBx mutants (M1, A1762T/G1764A; M2, T1674G+T1753C+A1762T/G1764A; M3, C1653T+T1674G+A1762T/G1764A; and Ct-HBx, carboxylic acid-terminal truncated HBx) were delivered into Sleeping Beauty (SB) mouse models.
Discussion: This result is consistent with a previous study demonstrating that the HBx with A1762T/G1764A (
Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients.
PMID: 34920100
2022
Infection, genetics and evolution
Abstract: A higher rate of A1635T, C1678T, A1727T, A1762T, G1764A, and C1773T was observed in cirrhotic patients.
Abstract: The frequency of C1481T/G1479A, T1498C, C1500T, G1512A, A1635T, C1678T, A1727T, and A1762T/ G1764A/ C1773T was significantly higher in cirrhotic patients compa
Regulatory function of interferon-inducible 44-like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes.
Abstract: METHODS: Primary human hepatocytes were infected with HBV using genomic plasmids carrying the basic core promoter mutation A1762T/G1764A and/or the precore mutation G1896A and treated with IFN-gamma and IFN-alpha.
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection.
Result: In addition, among these patients, 16 were infected with HBV strain harbouring basic core promoter (BCP) mutation A1762T/G1764A, whereas the remaining 45 patients were infected with BCP wild-type strain.
Molecular characterization of hepatitis B virus basal core promoter and precore region of isolates from chronic hepatitis B patients.
PMID: 34111075
2021
JPMA. The Journal of the Pakistan Medical Association
Abstract: Classic A1762T/G1764A double mutation was noted in 15(30%) isolates.
Increased hepatitis B virus quasispecies diversity is correlated with liver fibrosis progression.
PMID: 34029727
2021
Infection, genetics and evolution
Abstract: Specific mutations, such as A1762T, G1764A and G1896A, in the BCP/PC region were more common in patients with advanced liver disease and formed the majority of the viral quasispecies pool in patients with LC and HCC.
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
Result: The A1762T and G1764A mutations were found in two cases.
Table: G1764A
Discussion: Typically, BCP mutations (A1762T and G1764A) can reduce the mRNA synthesis of the pre-C region, which is reflected as a very low level of HBV DNA.
Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Abstract: APOBECs-related HBV mutations, including G1764A, were more frequent in the sera than in the adjacent tissues.
Abstract: HBV QC and A1762T/G1764A in the sera and tumors have contrary prognostic effects in HCC.
Abstract: High-frequent A1762T/G1764A in the sera predicted an unfavorable RFS (P < 0.001), whereas, in the tumors, it predicted a favorable RFS (P = 0.035).
HBV mutation literature information.
PMID: 
2022
Acta virologica
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