Comparative analysis of HBV basic core promoter/pre-core gene mutations and viral quasispecies diversity in HIV/HBV co-infected and HBV mono-infected patients.
Abstract: Among the patients infected with HBV genotype C and HBeAg-negative status, the frequency of A1762T/G1764A double mutations was significantly lower in HIV/HBV co-infected patients than in HBV mono-infected patients (53.3% vs.
Abstract: However, A1762T/G1764A double mutations did not differ in the other groups (P >0.05).
Regulatory function of interferon-inducible 44-like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes.
Abstract: METHODS: Primary human hepatocytes were infected with HBV using genomic plasmids carrying the basic core promoter mutation A1762T/G1764A and/or the precore mutation G1896A and treated with IFN-gamma and IFN-alpha.
Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients.
PMID: 34920100
2022
Infection, genetics and evolution
Abstract: A higher rate of A1635T, C1678T, A1727T, A1762T, G1764A, and C1773T was observed in cirrhotic patients.
Abstract: The frequency of C1481T/G1479A, T1498C, C1500T, G1512A, A1635T, C1678T, A1727T, and A1762T/ G1764A/ C1773T was significantly higher in cirrhotic patients compa
Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.
Result: Of these, T1753A and A1761C mutations were detected in one sample (HB55); and G1764T/A, C1766G/T, and C1773T mutations were detected in two samples (
Discussion: Moreover, the BCP A1762T and G1764A mutations are reported in association with HBV genotypes C and D.
Discussion: Of these, the pre-C mutation (G1896A) eliminates HBeAg expression at the translational level, whereas BCP mutations (G1764A) decrease HBeAg expression at the transcriptional level.
The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma.
Discussion: However, G1896A or A1762T/G1764A mutations were not found in this patient with genotype C HBV by DNA sequencing, while A1727T, C1730G and C1799G mutations were found in BCP region, which were reported to be associated significantly with cirrhosis.
Hepatitis B virus genome diversity in adolescents: Tenofovir disoproxil fumarate treatment effect and HBeAg serocon version.
Abstract: The basal core promoter (BCP) variants, A1762T and G1764A, and the pC variant, G1896A, were most often enriched at or after seroconversion.
Increased hepatitis B virus quasispecies diversity is correlated with liver fibrosis progression.
PMID: 34029727
2021
Infection, genetics and evolution
Abstract: Specific mutations, such as A1762T, G1764A and G1896A, in the BCP/PC region were more common in patients with advanced liver disease and formed the majority of the viral quasispecies pool in patients with LC and HCC.
Molecular characterization of hepatitis B virus basal core promoter and precore region of isolates from chronic hepatitis B patients.
PMID: 34111075
2021
JPMA. The Journal of the Pakistan Medical Association
Abstract: Classic A1762T/G1764A double mutation was noted in 15(30%) isolates.
Impacts of the Percentage of Basal Core Promoter Mutation on the Progression of Liver Fibrosis After Hepatitis B e Antigen Seroconversion.
PMID: 32860707
2021
The Journal of infectious diseases
Abstract: CONCLUSIONS: The percentage of A1762T/G1764A mutations after HBeAg seroconversion was associated with liver fibrosis.
Abstract: Hepatitis B e antigen seroconversion age is positively correlated with the percentages of A1762T/G1764A mutation at inflammatory phase before HBeAg seroconversion.
Abstract: RESULTS: We demonstrated that the percentages of A1762T/G1764A mutation are significantly higher in subjects with an LSM >7 kPa than in those with an LSM <=7 kPa after HBeAg seroconversion.
Abstract: Subjects who underwent interferon, entecavir, or tenofovir disoproxil
HBV mutation literature information.
PMID: 
2022
Acta virologica
Browser Board
Co-occurred Entities
Filtrator
ViMRT