Abstract: Conversely, the G1757A substitution was associated with protection, being 90% less frequent among patients with AdLD (P = 0.001).
Abstract: The results indicate that in genotype D CHB, the presence of the A1762T-G1764A mutation was associated with more aggressive liver disease while the G1757A substitution was associated with protection from advanced disease.
Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E.
PMID: 16425408
2005
World journal of gastroenterology
Abstract: Based on the sequences in the basic core promoter (BCP) to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.
Abstract: The specific nucleotide substitution G1757A in BCP,which might influence the virological characteristics, is observed in HBV/E.
Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers.
Result: The following substitutions appeared to be linked to the genotype (although not all the isolates of a determined genotype necessarily showed the mutation): G to A 1721 (found in genotype F), G to A 1757 (D), C to T 1802 (F), G to T 1803 (F), A to T 1850 (D and F), and C to T 1858 (D and F).