Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Discussion: Some studies revealed that the A1762/G1764A mutant accompanied by G1757A is associated with lower viral load and ALT level; hence, G1757A acts as an inhibitor to the A1762/G1764A mutant.
Discussion: When there is G1757A, the C1766G/G1764T double mutant is more efficient than the A1762T/G1764A mutation.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Result: According to different mutation regions, A1752T/G, T1753C, G1757A, A1762T/
Discussion: Other HBV mutations, which have been reported to relate to liver cirrhosis and HCC, including A1752T/G, T1753C, G1757A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, and G1898A, failed to show the association with patients' prognosis in the present study.
Molecular characterization of hepatitis B virus in Vietnam.
Result: T1753C, G1757A, A1762T, G1764A and C1766G mutations were identified in 11.1% (5/135), 7.4% (10/137), 25.9%% (35/135), 24.4% (33.135) and 2.2% (3/135) of the isolates and A1762T and G1764 T mut
Result: BCP/preC/core gene mutation: BCP mutations at T1753C, G1757A, A1762T, G1764 T and C1766G were analyzed and 30.4% (41/135) of all isolates including 78.4% (29/37) of the C1 isolates had at least one mutation.
Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity.
PMID: 26992056
2016
Journal of gastroenterology and hepatology
Abstract: METHODS: Direct sequencing of the precore/core gene was used to detect A1762T/G1764A and G1757A mutations in the BCP and G1896A and G1899A mutations in the PC region.
Abstract: RESULTS: The prevalences of A1762T/G1764A, G1757A, G1896A, and G1899A mutations were 34.1%, 38.7%, 54.9%, and 29.3% (P < 0.001), respectively.
Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Discussion: In addition, other combined mutation types such as C1856T/T1858C/G1721A and G1721A/G1757A/A1775G/T1858C were also exclusively detected in children with genotype C infection, while the clinical characteristics of these combined mutation-containing patients showed no statistical difference compared to those without combined mutations.
Variability in the precore and core promoter region of the hepatitis B virus genome.
Abstract: A novel association of mutation C1773T with G1764T, C1766A, and G1757A was also found within a site already suggested to be a putative binding site for HNF-3.
Abstract: This novel association is proposed by us to be of importance for additional binding of HNH-2 to this site and is a better indicator of the emergence of the double mutation G1764T and C1766A than the G1757A mutation proposed previously.
High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Result: The C1858T and G1757A substitutions were found in 226/228 (99.1%) and 189/228 patients (82.8%) respectively.
Table: G1757A
Discussion: A recent paper demonstrated that the G1757A substitution is associated with protection against advanced liver disease (P = 0.001).
Discussion: The low frequency of the PC mutation could be explained by the high prevalence of the G1757A mutation in our population.
Discussion: The low prevalence of the PC/BCP mutants in conjunction with the high percentage of the G1757A mutation might influence the clinical characteristics of HBV/E.
Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Discussion: The high replication capacity was mapped to nucleotides 1574-1986, where 7 core promoter mutations are present: G1751T, T1753A, G1757A, A1762T, G1764A, C1766T, and T1768A.
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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