Method: However, multivariate analysis that included G1730C, HBeAg, and age showed that the changing prevalence of G1730C was not independent of HBeAg and age (adjusted p = 0.222, 0.049, and 0.027, respectively).
Method: We noted a mild, but significant, decrease in the prevalence of G1730C mutations (p = 0.034).
Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Result: Seven mutation patterns (C1653T, G1719T, G1730C, T1753C, A1762T, G1764A, and G1799C) in the CP region were more prevalent in the patients with the C2 than with the B2 subgenotype (P<0.05).
Discussion: Univariate analyses showed that 6 mutation patterns (C1653T, G1730C, T1753C, A1762T, G1764A, and G1799C) located in the CP region were associated with LC compared with
HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations.
Abstract: HLA-DP polymorphisms promoting HBV clearance were associated with a lower prevalence of mutations increasing HCC risk (C1653T, T1674C/G, A1846T, G1896A and pre-S2 mutations and pre-S deletion in genotype C) and a higher prevalence of mutations decreasing HCC risk (G1652A, T1673C, T1674C, G1719T, G1730C, and G1799C in genotype B and A1727T in genotype C).
Investigation of DNA sequence in the Basal core promoter, precore, and core regions of hepatitis B virus from Tunisia shows a shift in genotype prevalence.
Result: All observed strains who carried mutations at nt 1726 (C to A), nt 1727 (T to A or G) and nt 1730 (G to C) in EnhII region, had BCP mutation at position 1802C-1803G.
Result: The samples of 39 patients containing wild-type strain at position 1721, had G1719T, C1726A, T1727A and G1730C mutations.
Result: The wild-type strain for nt 1703 present in 18 samples, had the wild-type at the positions 1701, 1702, 1721, 1728 and 1740, but had mutant-type at nt 1719 (G to T), nt 1726 (C to A), nt 1727 (T to A) and nt 1730
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
Table: G1730C
Discussion: Other mutations that have been shown to be statistically significantly associated with the risk of HCC, such as those at T31C, T53C, G1613A, A1703G, G1719T, C1726A, and G1730C, were not included because few patients had these mutations.
HBV mutation literature information.
PMID: 
2017
Emerging infectious diseases
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