Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.
Associations between serum HBX quasispecies and their integration in hepatocellular carcinoma.
PMID: 31966550
2017
International journal of clinical and experimental pathology
Abstract: In these, the HBX-integrated groups had significantly higher mutation frequencies at C1497T, A1630G, G1721A, A1762T/G1764A and A1774G.
Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Discussion: In addition, other combined mutation types such as C1856T/T1858C/G1721A and G1721A/G1757A/A1775G/T1858C were also exclusively detected i
Discussion: In our results, we showed that 16 of 17 T1858C mutation-containing sequences were in T1858C/A1775G/G1721A triple mutations.
Discussion: Statistical analysis demonstrated that the presence of a combined triple-mutation type, G1721A/A1775G/T1858C, was correlated with younger ages, genotype C strains, and a higher DNA load.
HBx mutants differentially affect the activation of hypoxia-inducible factor-1alpha in hepatocellular carcinoma.
Result: It was particularly interested to find that mutants A1630G and G1721A always appeared concurrently and that mutant A1762T constantly accompanied mutant G1764A.
Result: Of the double mutations A1630G/G1721A, the mutation G1721A does not lead to the alteration of HBx codon, and thus the double mutations affect only the codon 86 of the X protein (H86Y).
A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.
PMID: 19431214
2009
International journal of cancer
Abstract: Moreover, M1I and Q2K in pre-S2 gene and G1721A were more common in occult HBV-infected patients with HCC than in those without HCC.
Abstract: Multivariate analysis showed Q2K in pre-S2 gene, G1721A and A1846T were independent factors for occult HBV-infected HCC.
Abstract: The G1721A, M1I and Q2K in PMID: 11472634
2001
BMC microbiology
Result: The following substitutions appeared to be linked to the genotype (although not all the isolates of a determined genotype necessarily showed the mutation): G to A 1721 (found in genotype F), G to A 1757 (D), C to T 1802 (F), G to T 1803 (F), A to T 1850 (D and F), and C to T 1858 (D and F).
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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