Result: Similarly, the majority of the BCP mutations showed no significant difference among HBeAg status with the exception of A1676T (32.9%), C1678T/A (32.9%), G1719T (40.6%) and T1773C (18.9%) (Table 2) and the Kozak sequence mutant variants, which were higher in subjects with HBeAg negative status (Fig 2B).
Table: G1719T
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Result: Of those 19 hotspot mutations, C1653T, T1674C/G, A1703G, G1719T, T1727A/G, T1753C, A1762T, G1764A, G1799C, G1899A, G1915A/C, and C1969T were significantly associated with an increased risk of HCC, whereas C1673T, A1726C, C1730G, and A1752G were significantly associated with a reduced risk of PMID: 25942596
2015
PloS one
Discussion: Sixteen nucleotide differences between the two groups were found and seven of them (A1383C, R1479Y,
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
Result: We detected significant interactions between rs9272105 and the HBV mutations C1673T
Result: rs9272105 multiplicatively interacted with C1673T, G1719T, A1726C, C1730G, A1752G and G1799C.
Discussion: They sequenced the HBV EnhII/BCP/PC region successfully from 1,429 (52.2%) of the HBV-infected subjects and found that the interactions of rs9277535 AA with the T1674C/G or G1719T mutation in genotype C significantly decreased HCC risk.
Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.
Result: Amino acid transitions induced by G1719T, A1726C, A1752G/T and BCP A1762T/G1764A mutants had higher prevalence of 39.7% (23/58), 29.3% (17/58), 27.6% (16/58) and 31.0% (18/58), which mainly occurred in genotype C (21/23), genotype B (16/17), genotype B (13/16) and genotype C (16/18) infection patients, respectively.
Result: In addition, among the twelve hotspots, G1719T and T1753V were significantly associated with genotype C (P < 0.05), while A1726C and A1752G/T were genotype B related (P < 0.05) (Table 2).
Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
PMID: 23903686
2013
Brazilian journal of medical and biological research
Result: Seven mutation patterns (C1653T, G1719T, G1730C, T1753C, A1762T, G1764A, and G1799C) in the CP region were more prevalent in the patients with the C2 than with the B2 subgenotype (P<0.05).
Discussion: Seven of 13 mutation patterns (C1653T, G1719T, G1730C, T1753C, A1762T, G1764A, and G1799C) in the CP region were associated with C2 infection
HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations.
Abstract: HLA-DP polymorphisms promoting HBV clearance were associated with a lower prevalence of mutations increasing HCC risk (C1653T, T1674C/G, A1846T, G1896A and pre-S2 mutations and pre-S deletion in genotype C) and a higher prevalence of mutations decreasing HCC risk (G1652A, T1673C, T1674C, G1719T, G1730C, and G1799C in genotype B and A1727T in genotype C).
Abstract: The interaction of rs92775
Investigation of DNA sequence in the Basal core promoter, precore, and core regions of hepatitis B virus from Tunisia shows a shift in genotype prevalence.
Result: The samples of 39 patients containing wild-type strain at position 1721, had G1719T, C1726A, T1727A and G1730C mutations.
Result: The wild-type strain for nt 1703 present in 18 samples, had the wild-type at the positions 1701, 1702, 1721, 1728 and 1740, but had mutant-type at nt 1719 (G to T), nt 1726 (C to A), nt 1727 (T to A) and nt 1730 (G to C).
Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
PMID: 19574418
2009
Journal of the National Cancer Institute
Discussion: Other mutations that have been shown to be statistically significantly associated with the risk of HCC, such as those at T31C, T53C, G1613A, A1703G, G1719T, C1726A, and G1730C, were not included because few patients had these mutations.
HBV mutation literature information.
PMID: 
2018
PloS one
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