literature

HBV mutation literature information.

Molecular characteristics of occult hepatitis B virus from blood donors in southeast China.

PMID: 19940057 2010 Journal of clinical microbiology

Abstract: G145R was the major variation in the HBV isolates responsible for local occult HBV infections.

PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis-B surface antigen and anti-HBS antibodies.

PMID: 19950231 2010 Journal of medical virology

Abstract: Only two samples in Group I showed G145R/A mutation.

Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients.

PMID: 20034521 2010 Antiviral research

Abstract: The concomitant AA changes of HBsAg occurred in 16.67% (32/192) isolates including sG145R mutation.

Impacts of vaccination on hepatitis B viral infections in Korea over a 25-year period.

PMID: 20068337 2010 Intervirology

Abstract: In Korea, there have been no reported cases of HBV surface gene variants such as G145R.

Appearance of HbeAg in an occult persistent hepatitis B virus infection.

PMID: 20130415 2010 Intervirology

Abstract: A male patient with severe systemic diseases, positive for anti-HBc and anti-HBs and negative for all other HBV markers, including HBsAg, since at least 4 years, showed a positivity for HBeAg at a follow-up control in November 2008; HBV-DNA testing by real-time PCR evidenced very low levels of viremia (<40 IU/ml), direct sequencing of the surface antigen-coding and Pol/RT coding regions allowed the identification of genotype D, serotype adw2, one immune escape mutation (G145R) and no drug resistance mutations.

No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization.

PMID: 20210630 2010 The Journal of infectious diseases

Abstract: CONCLUSIONS: Less infectivity of G145R, recombinant vaccine use, and mutant loss with older age seem to decrease the a mutant prevalence in an immunized population over time.

Abstract: HBV DNA levels were significantly lower in hepatitis B e antigen-positive sera containing the G145R mutant than were levels in sera containing wild-type virus.

Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.

PMID: 20382061 2010 International journal of infectious diseases

Abstract: In the NUC therapy group the prevalence was 8.5% (12/142), with the following patterns: sY100C+sI110V, sL109I, sP120T, sP127T, sG130R+sG145X, sS132A+sY134N, sY134N+sG145R, s

Hepatitis B virus transfusion risk in China: proficiency testing for the detection of hepatitis B surface antigen.

PMID: 20409073 2010 Transfusion medicine (Oxford, England)

Abstract: The panel included four HBsAg-positive serum samples at concentrations of 0 16, 0 46, 0 9 and 1 73 IU mL(-1) ; three recombinant HBsAg mutants (G145R, T131I and K141E) with defined concentrations and one negative sample.

A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.

PMID: 20492719 2010 Virology journal

Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.

Result: C121Y(TGC TAC), T126S/T126A(ACT TCT or ACT GCT), Q129K(CAA AAA), G130R(GGA AGA), G145R(GGA AGA) and other aa substitution compared with consensus sequence in MHR were also showed in figure 2.

Discussion: A well-documented immune escape mutant G145R in one clone, mig

Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants.

PMID: 20516566 2010 Antiviral therapy

Abstract: Among vaccinated individuals with breakthrough HBV infection, sG145R & sT126A/S mutations (which account for 48% of the mutants detected) have become prominent.

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