Abstract: Several mutations were detected but not the common immune escape mutant G145R.
[The panels of serums, containing various subtypes and mutant forms of HBsAg, to evaluate the diagnostics sensitivity of kits oa reagents detecting HBsAg].
Abstract: The testing of reagents kits to detect HBsAg using twi panels containing recombinant and native variants of HBsAg, demonstrated that these kits enable to detect various sero-vatriants of HBsAg (ayw2, adw2, ayw3varA, ayw3varB, adrq-) in concentration 0.1-0.01 IU/l and the so called elusive mutant forms of HBsAg of recombinant and native origin (G145R, Q129R, Q129H, Q129L, T143K, T126N, T126S, D144A, M133L, K141E and P142S).
Molecular epidemiology of chronic hepatitis B virus infection in Greece.
1Abstract: Some of the most common mutations occurred at amino acid positions 129, 133, 134, 144, 145, including the ""vaccine escape"" mutation G145R."
Expression of Hepatitis B Virus Surface Antigen Containing Y100C Variant Frequently Detected in Occult HBV Infection.
PMID: 21331286
2011
Hepatitis research and treatment
Discussion: Viruses with G145R replacement have been almost invariably isolated as a major escape mutant after HBV vaccination.
Impact of universal vaccination on intrafamilial transmission of hepatitis B virus.
Abstract: Sequence analysis of S and pre-S genes showed that HBV isolates of HBsAg-positive vaccinees were variants; no G145R but G145A and other substitutions were found.
Posttransplantation prophylaxis with primary high-dose hepatitis B immunoglobulin monotherapy and complementary preemptive antiviral add-on.
Abstract: The Gly145Arg mutation was found in 11 of 15 (73.3%) patients, whereas 25 of 71 (35.2%), 2 of 29 (6.9%), and 4 of 8 (50%) patients were resistant to lamivudine, adefovir, and entecavir, respectively.
De novo activation of HBV with escape mutations from hepatitis B surface antibody after living donor liver transplantation.
Abstract: Sequence analysis revealed mutations in the common 'a' determinant region of the surface gene, including G145R, G145A and Q129P, in HBsAg.
Development and validation of a hepatitis B virus DNA sequencing assay for assessment of antiviral resistance, viral genotype and surface antigen mutation status.
PMID: 21723325
2011
Journal of virological methods
Abstract: The escape mutation sG145R in the surface antigen was identified in 0.8% of patient samples.
Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.
Result: Two patients in the add-on therapy group had sC137G amino acid substitutions (with rtL80M + rtM204I mutations), 2 patients in the switch therapy group had sG145R mutations (with rtN236T mutations), and 4 patients in the switch therapy group had sD144E mutations (1 patient with rtL80M + Discussion: Mutant sG145R is the most frequently reported modification and is a known vaccine escape mutant .
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: Replication-competent HBV strains with sG145R or sP120T and LAM resistance (rtM204I or rtL180M/rtM204V) were generated on an HBeAg-positive and an HBeAg-negative background with precore (PC) and basal core promoter (BCP) mutants.
Abstract: The sG145R mutation strongly reduced HBsAg levels and was able to full
HBV mutation literature information.
PMID: 
2012
Annals of hepatology
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