Abstract: CONCLUSIONS: Drug-resistant mutations rtM204I (sI195M) and rtM204V (sW196S) caused significant reduction in antigenicity for the immune-escaped HBsAg mutants sG145K and sG145R, which may hamper HBV diagnosis and disease control from HBV blood-transfusion transmissions in China.
Abstract: The combined effects of immune-escaped mutations (sT118M, sG145K, s
Late HBsAg seroreversion of mutated hepatitis B virus after bone marrow transplantation.
Abstract: Despite living without immunosuppressive agents for more than 40 months, she developed a fulminant HBV infection with detection of a mutated hepatitis B virus carrying two immune escape mutations (D144E/G145R) in the HBsAg (HBsIE mutation).
Con
Discussion: Interestingly, in both cases HBsIE double mutations were also identified (D144G/G145E and P142L/G145R).
Discussion: The presence of an uncommon double mutation (D144E/G145R) in HBsAg may indicate HBV reinfection from PBMCs because the mutation G145R appears to occur more often in PBMCs.
Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.
Result: In patient 1, changes of the P gene, rtW153Q, rtI169L, rtV173L, rtA181V, and rtM204V, corresponded to change of the S gene, rtG145R, rtF161H, rtE164D, and rtI195M, respectively (Table 4).
Renal transplantation from hepatitis B surface antigen (HBsAg)-positive donors to HBsAg-negative recipients: a case of post-transplant fulminant hepatitis associated with an extensively mutated hepatitis B virus strain and review of the current literature.
Abstract: RESULTS: Molecular analysis revealed multiple mutations in various open reading frames of HBV, the most important being the G145R escape mutation and a frameshift mutation-insertion (1838insA) within the pre-C/C reading frame.
Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.
Abstract: However, multiple HBV vaccine-escape mutations (sS143T + sD144E + sG145R + sE164D + sI195M) have been determined on the HBV overlapping pol/S gene region.
Change in hepatitis B virus large surface antigen variant prevalence 13 years after implementation of a universal vaccination program in China.
1Abstract: The prevalence of ""alpha"" determinant mutants in the children increased from 6.5% in 1992 to 14.8% in 2005, where the G145R mutant occurred most frequently."
[Clinical evaluation of a newly developed high-sensitive detection of hepatitis B virus surface antigen by a semi-automated immune complex transfer chemiluminescent enzyme immunoassay].
PMID: 24369590
2013
Rinsho byori. The Japanese journal of clinical pathology
Abstract: The sensitivity of wild type and HBsAg escape mutants (I126S, D144A, G145R) by ICT-CLEIA was 2- -5 to 2- -6 times higher than that of Architect HBsAg QT.
[Low prevalence of hepatitis B virus primary drug resistance in Southern Spain].
PMID: 23602529
2013
Enfermedades infecciosas y microbiologia clinica
Abstract: RESULTS: rtV173L, a lamivudine compensatory mutation, was detected in two patients (1.9%), rtI233V in one patient, and another one carried the sG145R vaccine escape mutation.
Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
1Abstract: Sequence analysis of S, pre-S, and overlapped polymerase (P) genes showed that HBV isolates of HBsAg-positive vaccinees were variants; no G145R but G145A and other substitutions were found in the ""a"" determinant."
8Discussion: We did not find the most important and best-documented G145R mutation, but we found a G145A mutation and other substitutions (T126I, N131T, and T143S) within the ""a"" determinant."
HBV mutation literature information.
PMID: 
2013
Virology journal
Browser Board
Co-occurred Entities
Filtrator
ViMRT