1Abstract: The prevalence of ""alpha"" determinant mutants in the children increased from 6.5% in 1992 to 14.8% in 2005, where the G145R mutant occurred most frequently."
Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants.
Abstract: CONCLUSIONS: Drug-resistant mutations rtM204I (sI195M) and rtM204V (sW196S) caused significant reduction in antigenicity for the immune-escaped HBsAg mutants sG145K and sG145R, which may hamper HBV diagnosis and disease control from HBV blood-transfusion transmissions in China.
Abstract: The combined effects of immune-escaped mutations (sT118M, sG145K, s
"Construction and expression of hepatitis B surface antigen escape variants within the ""a"" determinant by site directed mutagenesis."
1Abstract: RESULTS: Ten HBsAg mutants having single mutation within the ""a"" determinant including P120E, T123N, Q129H, M133L, K141E, P142S, D144A, G145R, N146S and C147S together with a wt form were successfully constructed and expressed in CHO cells."
Analysis of S gene mutation of the hepatitis B virus in adult liver transplant recipients showing resistance to hepatitis B immunoglobulin therapy.
Abstract: RESULTS: Various mutations in the MHR were observed in 14/15 samples: Gly145Arg mutation in 8/13 Adr subtype and 1/2 Ayw subtype samples (60%).
Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.
Discussion: Mutations related to diagnostic failure (such as M133T/I, F134N, and S143L) including vaccine escape mutations such as D144A and G145R could not be found.
[Clinical evaluation of a newly developed high-sensitive detection of hepatitis B virus surface antigen by a semi-automated immune complex transfer chemiluminescent enzyme immunoassay].
PMID: 24369590
2013
Rinsho byori. The Japanese journal of clinical pathology
Abstract: The sensitivity of wild type and HBsAg escape mutants (I126S, D144A, G145R) by ICT-CLEIA was 2- -5 to 2- -6 times higher than that of Architect HBsAg QT.
Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
1Abstract: Sequence analysis of S, pre-S, and overlapped polymerase (P) genes showed that HBV isolates of HBsAg-positive vaccinees were variants; no G145R but G145A and other substitutions were found in the ""a"" determinant."
8Discussion: We did not find the most important and best-documented G145R mutation, but we found a G145A mutation and other substitutions (T126I, N131T, and T143S) within the ""a"" determinant."
Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
Hepatitis B surface gene 145 mutant as a minor population in hepatitis B virus carriers.
Result: Although the girl with failure of immunoprophylaxis was positive for the mutant 1 probe, the G145R mutant was not detected as a predominant strain in any patients (Table 2).
Result: Consistent with the results of the mutant-specific real-time PCR, her electropherogram indicated that the wild-type HBV was the predominant strain and the G145R mutant was a minor strain.
Result: Detection of G145R mutant by cloning of PCR products.
Result: HBV DNA from clinical serum samples in which we had confirmed a mutation with G145R (at nt 587 G to A, genotype C, the levels of HBV DNA: 5.7 log copies/mL) was amplified using the mutant-specific real-time PCR in duplicate.
Result: In addition to the G145R mutant, the a determinant
Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.
HBV mutation literature information.
PMID: 
2013
Journal of virology
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