Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: The results of this study revealed the exclusive compartmentalization of HBV subgenotype Ae/A2-specific sequences with a potent immune escape G145R mutation in the PBL of the majority of the subjects.
Abstract: These results suggest that subgenotype Ae/A2 is selectively archived in the PBL, and the high prevalence of G145R indicates high immune pressure and high evolutionary rates of HBV DNA in the PBL.
"A function essential to viral entry underlies the hepatitis B virus ""a"" determinant."
1Abstract: Interestingly, G145R, a substitution often arising under immune pressure selection and detrimental to the ""a"" determinant, had no effect on infectivity."
[Analysis of clinical characteristics and S gene mutation of hepatitis B virus (HBV) in patients with hepatitis B surface antigen RIA negative and HBV DNA positive].
PMID: 19571620
2009
The Korean journal of laboratory medicine
Abstract: G145R mutation was found in 8 patients and G145K, D144G, and D144A were also frequently found.
A serological and molecular survey of hepatitis B in children 15 years after inception of the national hepatitis B vaccination program in eastern China.
Abstract: Mutations of I126T, amino acid 137 (nt553T deletion mutation), G145A, G145R, and F158S were found in the children; the mutations of amino acid 137 and F158S have not been reported previously.
[Surveillance for occult HBV infection and HBsAg variants in blood donors].
Abstract: Two of the patients in the study group had mutations at the positions sG145R and sC137G in the overlapped S-gene segment.
Clinical relevance and public health significance of hepatitis B virus genomic variations.
PMID: 19998495
2009
World journal of gastroenterology
Abstract: HBV mutations in the S genes, especially amino acids substitution at position 145 (G145R), are associated with immune escape, whereas mutations in the PreS or S genes which impair HBsAg secretion could present a risk to blood safety.
Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil.
Discussion: It has been shown that this triple mutant has a reduced in vitro affinity to anti-HBs antibodies, similar to what occurs with the hepatitis B vaccine escape mutant G145R.
Hepatitis B caused by a hepatitis B surface antigen escape mutant.
Abstract: Mutations were detected as I126S, T131N, S143T and G145R in 'a' determinant and L110F, I113S, T160K in up- or down-stream of 'a' determinant.
HBV mutation literature information.
PMID: 
2009
Journal of virology
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