literature

HBV mutation literature information.

Infectivity and vaccination efficacy studies in animal models of HBV S and pol gene mutants.

PMID: 20516568 2010 Antiviral therapy

Abstract: Infectious HBV wild-type and mutant clones were produced in vitro with three mutations in pol (rtV173L plus rtL180M plus rtM204V) or with a single mutation in the S gene (sG145R) and inoculated in treatment-naive chimpanzees.

Abstract: Intravenous inoculation of these mutants in chimpanzees resulted in HBV infection; the pol mutations remained stable, whereas the sG145R mutation reverted to wild type during viraemia.

A YIDD Mutation in a Case of Recurrent Hepatitis B after Liver Transplantation Induced by an S-escape Mutant.

PMID: 20559531 2010 Gut and liver

1Abstract: G145R and K141R mutations in the ""a"" determinant were detected only in the post-OLT sample."

Infection with hepatitis B virus carrying novel pre-S/S gene mutations in female siblings vaccinated at birth: two case reports.

PMID: 20573234 2010 Journal of medical case reports

Introduction: In 1990, a child developing protective antibody level after hepatitis B immunization was found to carry mutant HBV with a surface gene mutation at position 587 (guanine to adenosine), resulting in a change of glycine to arginine at amino acid 145 of the major surface antigen.

Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population.

PMID: 20675695 2010 Gut

Abstract: For those with viral sequence generation, none had the common HBsAg mutant G145R.

Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.

PMID: 20881037 2010 Journal of virology

Abstract: The M133T mutation could also overcome the secretion defect caused by the G145R immune-escape mutation or mutation at N146, the site of N-linked glycosylation.

Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan.

PMID: 19070923 2009 Journal of hepatology

Abstract: Sequence analyses of S gene showed occult isolates were variants; no G145R but C139S vaccine escape mutant was found.

Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection.

PMID: 19207682 2009 Journal of gastroenterology and hepatology

Abstract: None of the subjects had G145R mutation.

Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China.

PMID: 19212700 2009 Archives of virology

Abstract: Interestingly, Thr123Ala and Gly145Arg were observed only in failure-group mothers, whereas Thr126Asn, Thr126Ser, Thr143Asn, Asp144Gly, and Asp144Ala were seen in the success group.

Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model.

PMID: 19274751 2009 Hepatology (Baltimore, Md.)

Abstract: Prior to the HBV mutant challenge of vaccinated chimpanzees, we established virologic, serologic, and pathologic characteristics of infections resulting from intravenous inoculation of the HBV polymerase gene mutant and the sG145R vaccine-escape surface gene mutant.

Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.

PMID: 19301976 2009 The Journal of infectious diseases

Method: Mutations at 10 S envelope protein positions were considered possible vaccine-escape mutations, including sP120T, sI/T126N/A, sQ129H, sM133L, sK141E, sP142S, sD144A, sG145R, sF158Y, and s

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