Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs.
PMID: 26613893
2016
The Brazilian journal of infectious diseases
1Abstract: Mutation sI126S/T within the ""a"" determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity."
Clearance of HBV DNA in immunized children born to HBsAg-positive mothers, years after being diagnosed with occult HBV infection.
Abstract: The only still OBI-positive patient had an HBV DNA level of 50 copy/mL, carried the G145R mutation when tested in 2009 and again in 2013 in the 'a' determinant region of the surface protein.
High Burden of HBV-Infection and Atypical HBV Strains among HIV-infected Cameroonians.
Abstract: Of note, one HBV variant carried the vaccine-escape mutation G145R that hinders HBsAg neutralization by antibodies.
Occult hepatitis B virus infection and S gene escape mutants in HIV-infected patients after hepatitis B virus vaccination.
PMID: 26384943
2016
International journal of STD & AIDS
Abstract: Glycine to arginine mutation at residue 145 (G145R) within the 'a' region of the S gene was detected in one of the occult HBV infection cases who was in the non-responder group.
Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt.
Result: The well-known G145A/R variant was not observed in either the overt infection or occult infection group.
Hepatitis B vaccination.
PMID: 25483515
2015
Human vaccines & immunotherapeutics
Abstract: Beside G145R, other S-gene mutations potentially able to evade neutralizing anti-HBs and infect vaccinated people have been described worldwide.
Abstract: Since the G145R substitution alters the projecting loop (aa 139-147) of the a determinant, the neutralizing antibodies induced by vaccination are no longer able to recognize the mutated epitope.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
PMID: 25842192
2015
International journal of hematology
Abstract: Here, we report the first case of reactivation of resolved infection with the HBV immune escape mutant G145R in a CML patient receiving dasatinib.
[Occult hepatitis B virus infection in normal population, Xiamen].
PMID: 26081397
2015
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
1Abstract: 3 types of amino acid (AA) mutation (M133T, T140I, G145R) that influence ""a"" epitope conformation were observed in 9 subjects with occult HBV infection."
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The major population of MHR variants causing impaired of HBsAg secretion (e.g., G119R, Q129R, T140I, and G145R) was detected only in advanced liver disease patients.
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.
Molecular Characterization of Pre-Core/Core and S Region of Hepatitis B Virus in Hemodialysis Patients With Occult Hepatitis B Infection.
PMID: 26587212
2015
Jundishapur journal of microbiology
Discussion: determined three different S gene mutations (L109R, C137W, G145R) in a patient with occult hepatitis B, which led to false negative results for HBsAg but positive for HBsAb.
Discussion: reported that out of 239 HBsAg negative patients, nine (3.8%) were HBV-DNA positive and seven of the nine (78%) showed mutations in the S region (G145R).
HBV mutation literature information.
PMID: 
2016
The Brazilian journal of infectious diseases
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