The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia.
Abstract: Two HBV escape mutants were identified, G145R, reported worldwide, and W156*; this stop codon was identified in a child with occult HBV infection.
Discussion: G145R is considered as a potential cause of a public health problem in countries with a universal vaccination program.
Discussion: Escape mutant G145R was the first one described in a serum sample obtained from an Italian vaccinated child.
Discussion: In regions with high prevalence of infection, where these variants have been found, the recommendation is to implement new vaccines containing the common escape mutants, mainly G145R.
Discussion: The present study identified two HBV escape mutants (G145R, W156*)
Molecular evolution of hepatitis B vaccine escape variants in China, during 2000-2016.
Abstract: Four sites (A5T/S, L21S, T/A126S and T/N131I/A) and 13 sites (N3S, T5A, G10Q/R/E, L21S, T47K/A/V, L98V/P, I/S126N/V/T, Q129H/R/L, T131P/I/N/A, G145A/R, L175S/F, L213I/S, V224A/G) were found to be under positive selection in genotype B and C HBV vaccine escape strains, re
Eradicating hepatitis B virus: The critical role of preventing perinatal transmission.
Abstract: Most late infections with sG145R were in vaccine non-responders, suggesting escape from HBIG rather than from vaccine-induced antibody.
Abstract: New analyses of our data from US trials of HBIG and HBV vaccine in high-risk infants revealed better efficacy with yeast-recombinant vaccine than plasma-derived vaccine, especially in preventing late onset infections, with evidence that vaccine prevented transmission of maternal HBV infection with the glycine to arginine mutation in surface antigen codon 145 (sG145R).
Hepatitis B reactivation characterized by HBsAg negativity and anti-HbsAg antibodies persistence in haematopoietic stem cell transplanted patient after lamivudine withdrawal.
Conclusion: This concept agrees with a previous study, which showed that the viral clones encoding S204R (lysine [S] substitution with arginine [R] at position 204) and G145R (glycine [G] substitution with arginine [R] at position 145) exhibited an approximately 60% viral secretion defect compared with the wild-type.
Molecular characterization of hepatitis B virus in Vietnam.
4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence ass
5Result: Among the isolates, 8.1% (11/135) had a mutation in the ""a"" determinant region including 2.2% (3/135) P120S/T, 2.2% (3/135) I/T126S/A, 3% (4/135) M133 L/T and 0.7% (1/135) G145R."
Table: G145R
Impact of deletions and mutations in Hepatitis B virus envelope proteins on serological profile and clinical evolution.
Abstract: CD8+/CD4+ T-cell epitopes and B-cell epitopes in the major hydrophilic region (MHR), such as sI126N and sG145R possibly involved in the rare coexisting Hepatitis B surface Antigen (HBsAg)/anti-HBs serological pattern.
Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B.
Discussion: The resistance mutations rtL180M + rtM204V and rtS202I may be associated to the presence of mutations in the coding region of the HBsAg envelope region (S of the HBV), as found in the patterns I195M, W196L, and G145R, indicating vaccine escape.
Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.
8Discussion: Of the 11 positions where mutations occurred in ""alpha"" determinant region, the most frequent mutation position was aa 126 (I126S/N and T126A, 29.63%), and 145 (G145R/A, 25.93%), all of which were known to act as VEMs, accounting for more than half of the total mutation strains wither the ""alpha"" determinant."
Result: Eight types of these mutations (I126S,
Discussion: Again, an in vitro model revealed that HBV with a G145R mutation shared the replication efficacy with equal to wild-type virus.
Discussion: The well-known G145R/A mutations were often found in vaccination failure settings.
Discussion: confirmed that G145R virus could circulate as a stable strain for 8 years of follow-up.
Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs.
PMID: 26613893
2016
The Brazilian journal of infectious diseases
1Abstract: Mutation sI126S/T within the ""a"" determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity."
HBV mutation literature information.
PMID: 
2017
PloS one
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