Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Deep sequencing of hepatitis B surface antigen gene in the preserved umbilical cords in immunoprophylaxis failure against mother-to-child HBV transmission.
Discussion: In the animal experiment, chimpanzees were protected from infection of VEMs (G145R) by a recombinant HB vaccine.
Discussion: One of our previous studies demonstrated that four of six children who were chronically infected with HBV due to a breakthrough infection had the G145R mutant had a minor population in their serum.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Nucleic Acid Polymers Are Active against Hepatitis Delta Virus Infection In Vitro.
Abstract: NAP antiviral activity was effective against HDV virions bearing the main hepatitis B virus (HBV) immune escape substitutions (D144A and G145R) and was pangenomic with regard to HBV envelope proteins.
Occult Hepatitis B Virus Infection and Associated Genotypes among HBsAg-negative Subjects in Burkina Faso.
PMID: 29326804
2018
Mediterranean journal of hematology and infectious diseases
1Abstract: A single ""false OBI"" strain had the characteristic mutation G145R."
5Result: A single strain of ""false OBI ""carried the G145R mutation (Table 3)."
8Discussion: The presence of same mutations in addition to that of G145R in ""false OBI"" cases of this study confirms the conclusion of the statements from the Taormina expert meeting on occult hepatitis B virus infection."
Discussion: In addition, the role of the G145R mutation has been clearly established by several studies in vaccine escape.
Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
Abstract: The major vaccine-induced escape mutation G145R was observed in two samples.
Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.
Discussion: Several specific mutations, including G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R, have been reported as being related to the decrease of HBsAg secretion.
Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Discussion: Furthermore, mixed expression of L/M/S proteins of the G145R or N146Q mutant with just S protein of WT virus or the M133T mutant rescued virion secretion.
Discussion: Immune escape mutations such as G145R reduce the affinity of the mutant envelope proteins for anti-HBs antibody, thus leading to diagnostic failure, occult HBV infection, vaccine failure and breakthrough infection despite presence of neutralizing antibodies against WT S domain.
Discussion: In our previous study, a G112N mutation (creating a glycosylation site at residue 112) partially rescued virion secretion of the G119E
A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.
Introduction: Whilst the S protein mutation sG145R has been identified as the major VEM, recently other mutations in S protein have been associated with immune escape Fig 1.
Result: Another significant VEM, sG145K/R, was identified in six studies and sM133L/T, associated with VEM, immunoglobulin and diagnostic escape mutation, was identified in seven studies (Fig 2).
HBV mutation literature information.
PMID: 
2019
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