[Identification of hepatitis B virus genotypes in patients with chronic hepatitis B from different nationalities in ethnic minority areas in Yunnan Province, China].
Abstract: In all subjects, the frequency of aa G145R (0.4%) substitutions was less than 1%.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: Mutant G145R along with T118V and T143M was identified in three subjects who included one 1 degrees, one 2 degrees, and one 3 degrees contact.
Abstract: Of these three contacts with G145R mutation, only one 1 degrees contact was found to be HBsAg-ve.
Abstract: Presence of T118V and T143M mutations along with G145R mutation in these subjects provides an indirect evidence for the possible horizontal transmission of G145R HBV variant to a 3 degrees unrelated contact.
Abstract: The data also reaffirms the earlier finding of HBsAg positivity in presence of G145R mutation of the
[Characterisation of an HBsAg mutant of hepatitis B virus (HBV) isolated from a dialysed patient involved in an occupational accident].
Abstract: They consist most commonly of an aminoacid change from glycine to arginine at position 145 of the highly antigenic a determinant of the surface antigen (HBsAg).
[The incidence rate of hepatitis B virus surface gene variants in Korean children with immunoprophylaxis failure of perinatal infection].
PMID: 16380661
2005
The Korean journal of hepatology
Abstract: CONCLUSIONS: In Korea, compared to the previous studies of other nations, gene surface variants such as G145R do not appear to play an important role in perinatal immunoprophylaxis failure.
Clade analysis and surface antigen polymorphism of hepatitis B virus American genotypes.
Abstract: One isolate obtained from a blood donor could not be classified in any clade and harbored amino acid substitutions characteristic of a vaccine escape mutant (G145R) and a stop codon in the surface antigen.
Evaluation of sensitivity for wild type and mutant forms of hepatitis B surface antigen by four commercial HBsAg assays.
Discussion: It has been shown that this triple mutant has a reduced in vitro affinity to anti-HBs antibodies, similar to the hepatitis B vaccine escape mutant G145R.
Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan.
Abstract: RESULTS: The prevalence of a determinant mutants in HBV-DNA positive children was 7.8% (8/103) in 1984, which significantly increased to 19.6% (10/51) in 1989, peaked at 28.1% (9/32) in 1994, and remained at 23.1% ((3/13) (T131I, G145R, G145R)) in 1999; it was higher in those fully vaccinated compared with those not vaccinated (15/46 v 15/153; p<0.001).
Replication and gene expression of mutant hepatitis B virus in a transgenic mouse containing the complete viral genome with mutant s gene.
PMID: 15457560
2004
World journal of gastroenterology
Abstract: Founders with HBsAg in serum were named lineages G145R-15 and G145R-18.
Abstract: Of the 16 F1 offsprings generated by G145R-15 founder, 12 were positive for HBV genome with PCR, 10 were positive for HBsAg and HBcAg with immunohistochemistry and 7 were positive for HBsAg and HBeAg with ELISA.
Abstract: Only 1 of 8 F1 offsprings generated by G145R-18 founder was survived and it was detected positive for HBV genome, HBsAg, HBcAg and HBeAg.
Occult hepatitis B virus infection in a North American adult hemodialysis patient population.
HBV mutation literature information.
PMID: 
2006
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