Discussion: In line with this hypothesis, a previous study showed that the sS204R mutation in S-HBsAg C-terminus (along with G145R) exhibited a viral secretion defect compared to the wild-type.
Mutation in the S gene of hepatitis B virus and anti-HBs subtype-nonspecificity contributed to the co-existence of HBsAg and anti-HBs in patients with chronic hepatitis B virus infection.
Abstract: Besides, some HBsAg variations in group I patients, sG145R mutation, inserted mutations, and continuous aa mutations within the major hydrophilic region (MHR), decreased the neutralized capacity of anti-HBs from HBV vaccinated persons.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: Amino-acid (aa) substitution from glycine to arginine at aa 145 (G145R), in the major hydrophilic region, has been reported in patients with HBsAg and anti-HBs coexistence.
Abstract: However, there is limited knowledge about the clinical features and viral quasispecies characteristics associated with G145R mutant hepatitis B virus (HBV) infection.
Abstract: The quasispecies characteristics of the G145R mutant HBV were investigated via ultra-deep sequencing.
Abstract: We herein describe the dynamic changes in the serological and virological markers in a case of hepatitis B with coexisting HBsAg and anti-HBs, caused by a G145R immune escape mutant (genotyp
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Introduction: Finally, the rising anti-HBs antibodies can select for amino acid substitutions in the antigenic epitopes in the S protein such as G145R.
Result: The G145R immune escape mutation caused low S protein level by Western blot.
Discussion: Among the missense mutations analyzed (D99G, P120T, C121Y, I126S, G145R, and R160G), only D99G caused HBsAg-negative phenotype.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
Result: One well described vaccine-escape mutation, sG145R, occurred in two patients.
Discussion: In this cohort we found two patients with the well-described G145R mutation, as well as several patients with other mutations potentially leading to immune escape (including 'a' determinant sites 126, 129, 130, 131 and 144).
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Result: Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment.
Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.
Result: Three strains had mutations within E2 plus additional mutations outside of E1 and E2; S143SL, T131TN, and M133MT (n = 1), D144A, G145A, and M133I (n = 1), and G145R, T126TI, and Y134YN (n = 1).
Molecular evolution of hepatitis B vaccine escape variants in China, during 2000-2016.
Abstract: Four sites (A5T/S, L21S, T/A126S and T/N131I/A) and 13 sites (N3S, T5A, G10Q/R/E, L21S, T47K/A/V, L98V/P, I/S126N/V/T, Q129H/R/L, T131P/I/N/A, G145A/R, L175S/F, L213I/S, V224A/G) were found to be under positive selection in genotype B and C HBV vaccine escape strains, re
Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.
Abstract: Two HBV escape mutants were identified, G145R, reported worldwide, and W156*; this stop codon was identified in a child with occult HBV infection.
Discussion: G145R is considered as a potential cause of a public health problem in countries with a universal vaccination program.
Discussion: Escape mutant G145R was the first one described in a serum sample obtained from an Italian vaccinated child.
Discussion: In regions with high prevalence of infection, where these variants have been found, the recommendation is to implement new vaccines containing the common escape mutants, mainly G145R.
Discussion: The present study identified two HBV escape mutants (G145R, W156*)
The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia.
HBV mutation literature information.
PMID: 
2017
Oncotarget
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