Occult HBV infection in patients with autoimmune hepatitis: A virological and clinical study.
PMID: 31153830
2020
Journal of microbiology, immunology, and infection
Abstract: In addition to those already reported OBI-associated AA substitutions (e.g., sG145R and sV184A), some new OBI-associated AA substitutions (e.g., sV106A, sC137* and sL176P) were found in AIH patients in our study.
Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.
Result: In particular, significant differences in the frequency of G145R were observed within genotypes C and D, with the highest rates recorded for subgenotypes C6-C15 and D2 (34 and 8.2%, P < 0.001 for both; Tables 2-6).
Result: Notably, G145R was only detected in genotypes G (5.0%), D (2.5%), C (2.1%), and B (0.2%) (P < 0.001) (Table 1).
Result: The most common substitutions were I/T126S (1.8%), G145R (1.2%), M133T (1.2%), Q129R (1.0%), I/T126A (0.8%), and P120T (0.8%).
Result: These major mutations were more frequent in genotypes A (P120T, 3.2%), B (I/T126A, 2.8%; Q129R
Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Introduction: Moreover, some of the mutations in HBsAg, such as D144A, Q129R, and G145R, could reduce binding to HBsAbs from the hepatitis B vaccination, bypassing the neutralizing activity of these antibodies (antibody escape) and result in infecting HBV-vaccinated individuals.
Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy.
PMID: 30771531
2019
Clinical microbiology and infection
Abstract: Antibody affinity to sG145R and the IFN-gamma-secreting cell response to some epitope 16-33 variants were still impaired even after booster administration.
Abstract: IFN-gamma-secreting T cells to epitope 16-33 containing R24K and the antibody affinity to sG145R were still significantly lower than to the wild type.
Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.
Abstract: A phosphorylation site (target for protein kinase C) produced by the G145R substitution might prevent recognition by anti-HBs antibodies.
Abstract: Prediction of the tertiary structure of subgenotypes F1b and F4 revealed changes inside and outside the major hydrophilic region (aa 101-160) of the HBsAg compared to genotype A and the G145R variant.
Abstract: This study examined the effect of virus-like particles containing HBsAg from genotypes A and F (particularly, F1b and F4) produced in Pichia pastoris in relation to the anti-HBs antibodies used in the immunoassays for in vitro diagnosis and compared it with that exerted by the G145R S-escape mutant.
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.
R
Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.
PMID: 30906435
2019
Experimental and therapeutic medicine
Result: In the present study, the most prevalent mutations were those in the S region (sP120Q, sQ129R, sT131I, sM133I, sG145R, sY161F/H, sI195M/T, s
Discussion: sP120T and sG145R) that may be associated with LAM resistance, were not detected in the present study.
HBV mutation literature information.
PMID: 
2020
Journal of microbiology, immunology, and infection
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