1Abstract: Mutations on the ""a"" determinant (Thr126Ser, Gly145Arg, a double mutant Thr126Ser/Gln129Asn, Met 133Leu and Thr140Ile) were identified in 5 samples while the wild type sequence was found in 2 others."
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: CONCLUSIONS: The G145R mutant could be transmitted horizontally among family members, and this could occur in the presence of high levels of anti-HBs.
Abstract: Improvement of detection system for the G145R and other HBsAg mutant will be needed for their effective control.
Abstract: In addition, liver damage was seen in one G145R carrier infant.
Abstract: In families 2 and 3, the G145R mutant detected previously in child 1 was detected in the father.
Abstract: METHODS: Serum samples from family members of 10 vaccinated infants who carried this G145R mutant were collected.
Abstract: OBJECTIVES: To provide intra-familial evidence on the horizontal transmission
Detection of hepatitis B surface antigen mutants and their integration in human hepatocellular carcinoma.
Abstract: Southern blot analysis indicated that the HBsAg mutant with the Glycine to Arginine change at position 145 was integrated in HCC, whereas those with a Threonine at position 133 instead of a Methionine were identified in the serum of aggressive HCC.
Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir.
Abstract: Both the wild type HBV and lamivudine-related mutants with the Gly145-->Arg145 HBsAg mutation were suppressed following ganciclovir treatment, indicating a beneficial additive effect of both drugs against different forms of HBV mutants.
Abstract: The same virus carried a HBsAg Gly145-->Arg145 mutation prior to therapy.
Liver graft infection by HBV S-gene mutants in transplant patients receiving long-term HBIg prophylaxis.
Abstract: CONCLUSIONS: These data demonstrate that long-term polyclonal anti-HBs immunoprophylaxis selected the most commonly described G145R S-gene escape HBV variant which became the dominant virus population and was responsible for graft infection.
Abstract: Therefore, immunoglobulins with high affinity for the G145R HBs variant should be included in HBIg to prevent recurrent HBV infection in transplant patients.
Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues.
Abstract: The mutation Gly145Arg, which has been reported to be associated with immunoevasion, was found in seven of the 18 HCC tissues.
Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.
Abstract: In addition to already-known variants sG145R/K/E, we could demonstrate that newly described variants sX144G and sG145A were antigenically altered and showed impaired recognition by polyclonal HBIG in vitro.
Incidence and clinical consequences of surface and polymerase gene mutations in liver transplant recipients on hepatitis B immunoglobulin.
Abstract: The most frequently identified amino acid substitution was glycine to arginine at position 145 (present in 4 of 6 patients who failed HBIg after at least 6 months of treatment).
Current aspects of hepatitis B surface antigen mutants in Singapore.
Abstract: These vaccine-escape HBsAg mutants display a predominance of the Gly145-to-Arg145 mutation in the antigenic 'a' determinant.
Infectivity and pathogenicity in chimpanzees of a surface gene mutant of hepatitis B virus that emerged in a vaccinated infant.
PMID: 9041321
1997
The Journal of infectious diseases
Abstract: Dilutions of serum that contained the first such described HBV mutant, with an Arg-for-Gly substitution at codon 145 of the S gene, were inoculated into 6 seronegative chimpanzees.
HBV mutation literature information.
PMID: 
2000
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