Abstract: The reactivated virus was HBV genotype F3 with vaccine escape mutations G145R, P120Q, and Q129P.
Conclusion: We found eight mutations and amino acid substitutions in the
Introduction: Specific single mutations, such as G145R, disrupt the structure of this epitope domain so that neutralizing antibodies (anti-HBs) cannot recognize it, thereby eliminating protection.
Discussion: To the best of our knowledge, this is the first case describing breakthrough of HBV genotype F due to G145R, P120Q, and Q129P escape mutations in a transplant setting.
Discussion: We identified the immune escape mutation G145R in our patient.
A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.
Introduction: Whilst the S protein mutation sG145R has been identified as the major VEM, recently other mutations in S protein have been associated with immune escape Fig 1.
Result: Another significant VEM, sG145K/R, was identified in six studies and sM133L/T, associated with VEM, immunoglobulin and diagnostic escape mutation, was identified in seven studies (Fig 2).
Table: G145A/R
Table: G145R
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: Notably, these authors also found that RT mutations in the A-B interdomain could lead to simultaneous AA substitutions sI126A/N/S/, sG130N, sT131N/P, and sG145R of the overlapped 'a' determinant of HBsAg, including the most frequently described immune-escape mutation sG145R (1/192, 0.52%).
Table: G145R
Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.
Result: Amino acid substitutions associated with immune escape, such as sT118K (n = 3), sG145A (n = 3), and sG145R (n = 1) variants, were abundant, especially in non-HSCT patients at HBV reactivation.
Result: In addition, several variants in the immunodominant loop of surface protein, including sT118K, sQ129H, and sG145R substitutions in the small S protein are reported to induce impaired virion secretion from infected liver cells.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
Result: One well described vaccine-escape mutation, sG145R, occurred in two patients.
Discussion: In this cohort we found two patients with the well-described G145R mutation, as well as several patients with other mutations potentially leading to immune escape (including 'a' determinant sites 126, 129, 130, 131 and 144).
Mutation in the S gene of hepatitis B virus and anti-HBs subtype-nonspecificity contributed to the co-existence of HBsAg and anti-HBs in patients with chronic hepatitis B virus infection.
Abstract: Besides, some HBsAg variations in group I patients, sG145R mutation, inserted mutations, and continuous aa mutations within the major hydrophilic region (MHR), decreased the neutralized capacity of anti-HBs from HBV vaccinated persons.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: Amino-acid (aa) substitution from glycine to arginine at aa 145 (G145R), in the major hydrophilic region, has been reported in patients with HBsAg and anti-HBs coexistence.
Abstract: However, there is limited knowledge about the clinical features and viral quasispecies characteristics associated with G145R mutant hepatitis B virus (HBV) infection.
Abstract: The quasispecies characteristics of the G145R mutant HBV were investigated via ultra-deep sequencing.
Abstract: We herein describe the dynamic changes in the serological and virological markers in a case of hepatitis B with coexisting HBsAg and anti-HBs, caused by a G145R immune escape mutant (genotyp
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Result: Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment.
Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.
Result: Three strains had mutations within E2 plus additional mutations outside of E1 and E2; S143SL, T131TN, and M133MT (n = 1), D144A, G145A, and M133I (n = 1), and G145R, T126TI, and Y134YN (n = 1).
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Introduction: Finally, the rising anti-HBs antibodies can select for amino acid substitutions in the antigenic epitopes in the S protein such as G145R.
Result: The G145R immune escape mutation caused low S protein level by Western blot.
Discussion: Among the missense mutations analyzed (D99G, P120T, C121Y, I126S, G145R, and R160G), only D99G caused HBsAg-negative phenotype.
HBV mutation literature information.
PMID: 
2018
World journal of hepatology
Browser Board
Co-occurred Entities
Filtrator
ViMRT