[Identification of vertical transmission of hepatitis B virus from mother to children by direct sequencing a segment of surface gene of hepatitis B virus].
Abstract: In one child of family three, with coexisted HBsAg and anti-HBs, sequencing result revealed a point mutation which predicted a change from glycine to arginine at residue 145 in the second loop of the determinant.
Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA.
Abstract: PCR sequencing revealed a substitution of arginine for glycine at position 145 of HBsAg in the major neutralising epitope cluster, the a determinant, as well as a 2-aminoacid insertion of asparagine and threonine between positions 122 and 123, immediately upstream of this determinant.
[Expression of 12 antibody escape mutants of hepatitis B virus surface antigen gene in mammalian cell by using an Epstein-Barr based vector].
Abstract: The results of detection of HBsAg excreted by resistant cell clones with monoclonal antibody to HBsAg showed that all antibody escape mutants of HBsAg except mutant 145R, a substitution of arginine for glycine at amino acid 145 position in HBsAg, were positive.
Mutations of some critical amino acid residues in the hepatitis B virus surface antigen.
Abstract: Mutation of cysteine 149 to serine or of glycine 145 to arginine (imitating naturally occurring mutants), lysine, or glutamatic acid all led to loss of cross-reactivity with polyclonal antisera.
Glycine-to-arginine substitution at codon 145 of HBsAg in two infants born to hepatitis B e antigen-positive carrier.
PMID: 7895545
1995
Digestive diseases and sciences
Abstract: Amino acid residues 122-160 of HBsAg were identical between the daughters and their mother except for a glycine-to-arginine substitution at codon 145.
A family cluster of an immune escape variant of hepatitis B virus infecting a mother and her two fully immunized children.
PMID: 8574843
1995
Clinical and diagnostic laboratory immunology
Abstract: A hepatitis B virus (HBV) immune escape variant which results from a substitution of glycine by arginine at position 145 (arginine-145) in the immunodominant neutralization epitope of the S protein was found to infect one child in a seroepidemiologic survey of 1,812 vaccinated children.
"Loss of the common ""A"" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant."
PMID: 1281839
1992
The Journal of clinical investigation
Abstract: A substitution of arginine for glycine at amino acid 145 in HBsAg was observed.
HBV mutation literature information.
PMID: 
1996
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