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 HBV mutation literature information.


  A low rate of hepatitis B virus vaccine breakthrough infections in Mongolia.
 PMID: 17063521       2006       Journal of medical virology
1Abstract: A G145A ""escape mutant"" was found in one HBV carrier child only."


  Prevalence of vaccine-induced escape mutants of hepatitis B virus in the adult population in China: a prospective study in 176 restaurant employees.
 PMID: 11851835       2001       Journal of gastroenterology and hepatology
Abstract: Four out of these six cases had a point mutation within the 'a' determinant; they were Gly-145-Ala, and Ile/Thr-126-Asn/Ser.


  Hepatitis B surface antigen variants in vaccinees, blood donors and an interferon-treated patient.
 PMID: 11264736       2001       Journal of viral hepatitis
Abstract: One child had a double mutation (P142S and G145R) and the other a G145A substitution.


  Analysis of HBs antigen negative variant of hepatitis B virus: unique substitutions, Glu129 to Asp and Gly145 to Ala in the surface antigen gene.
 PMID: 11208474       2000       Medical science monitor
Abstract: Also, HBV variant with substitution at position 145 (Gly to Ala) has been recently reported to be antigenically altered and to show impaired recognition by polyclonal hepatitis B hyperimmune globulin in vitro.
Abstract: Rare substitution was identified both at positions 129 (glutamine to asparagine) and at position 145 (glycine to alanine) in the 'a' determinant region, which is considered to be within a larger antigenic area known as the major hydrophilic region (MHR).


  Liver graft infection by HBV S-gene mutants in transplant patients receiving long-term HBIg prophylaxis.
 PMID: 10430358       1999       Hepato-gastroenterology
Abstract: A HBV S-gene mutant containing a G to A nucleotide mutation at position 587, converting Glycine to Arginine (G145A), was identified in all three patients as the dominant population at reinfection but not pre-transplantation.


  Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.
 PMID: 9425945       1998       Hepatology (Baltimore, Md.)
Abstract: In addition to already-known variants sG145R/K/E, we could demonstrate that newly described variants sX144G and sG145A were antigenically altered and showed impaired recognition by polyclonal HBIG in vitro.


  Molecular analysis of the a determinant of HBsAg in children of HBeAg-positive mothers upon failure of postexposure prophylaxis.
 PMID: 9763505       1998       International journal of infectious diseases
Abstract: Only two exhibited a point mutation within the a determinant, one of which consisted of a substitution of glycine with alanine at position 145, and the other of a substitution of glutamine with arginine at position 129.


  Hepatitis B virus strains in Thailand: genomic variants in chronic carriers.
 PMID: 8636719       1995       Journal of medical virology
Abstract: Glycine 145 was changed to alanine in one strain, and this position showed an apparent mixture of glycine and arginine in another.


  Variant of hepatitis B virus isolated in Zimbabwe.
 PMID: 8308523       1994       Journal of medical virology
1Abstract: Within the second loop of the ""a"" determinant, two mutations resulting in substitution of serine or threonine with the hydrophobic amino acids, methionine at position 143 and with alanine in place of glycine at position 145, are predicted from the consensus nucleotide sequence of the PCR-derived clones."



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