Discussion: Thirteen MHR mutations (G119R, P120T, C124R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, G145A, and G145R) were detected and functionally characterized in vitro and in vivo.
S gene mutants occurrence among hepatitis B carriers in malaysia.
Discussion: The MHR region contains residues 99-169 of HBsAg and T/I126S, Q129H, G130N, S143L, D144A, G145A, and G145R were among the commonly reported mutations.
Epidemiological, virological and clinical characteristics of HBV infection in 223 HIV co-infected patients: a French multi-centre collaborative study.
1Abstract: Sequence analysis of S, pre-S, and overlapped polymerase (P) genes showed that HBV isolates of HBsAg-positive vaccinees were variants; no G145R but G145A and other substitutions were found in the ""a"" determinant."
5Result: Within the ""a"" determinant, one (N131T) substitution was detected in all isolates and three additional variants (T126I, T143S, and G145A) were found in subject Y5 (Table 3)."
8Discussion: We did not find the most important and best-documented G145R mutation, but we found a G145A mutation and othe
Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.
Abstract: Site-directed mutagenesis was then utilized to introduce three genotype A mutations - M103I, K122R and G145A - associated with occult HBV infection in vivo, alone and in combination, into the wild-type HBsAg vectors.
Abstract: The G145A mutation resulted in significantly decreased extracellular and intracellular HBsAg expression in vitro.
Introduction: Finally, G145A was reported in one O-HBV infection of unknown genotype.
Introduction: Three O-HBV mutations - M103I, K122R, and G145A - from a genotype A infection wer
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Abstract: In the immunodominant 'a' region of the surface gene, point mutations were identified in 31% (n = 58/187) of sequences, and 2.2% (n = 4/187) and 5.3% (n = 10/187) specimens contained the major vaccine escape mutations G145A/R and P120L/Q/S/T, respectively.
Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1),
[Heterogeneity of hepatitis B virus and diagnostic potential of modern test systems for the detection of HBsAg].
PMID: 22442974
2012
Zhurnal mikrobiologii, epidemiologii i immunobiologii
Abstract: Amino acid substitutions G145A, M133I, S132T localized in the main hydrophilic region and P217L, S207N, V184A localized in the C-end of the protein C that are connected with diagnostic and vaccine escape were identified in 5 isolates.
Abstract: Approximately equal potential of 6 test systems to detect HBsAg with amino acid substitutions G145A, M133I and S132T localized in the MHR region were shown.
Hepatitis B surface gene 145 mutant as a minor population in hepatitis B virus carriers.
Abstract: To detect the G145R and G145A mutants in patients, we designed 3 probes for real-time PCR.
Method: Real-time PCR for the G145R and G145A mutants.
Method: The point mutation at nt 587 (G145R, mutant 1: G to A, mutant 2: G to C) and nt 588 (G145A, mutant 3: G to C) were applied to the sequence of the probes.
Method: To detect the G145R and G145A mutants as minor strains in patients, we designed 3 probes based on the sequences of the G145R and G145A mutants.
HBV mutation literature information.
PMID: 
2014
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