literature

HBV mutation literature information.

Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.

PMID: 28591184 2017 PloS one

Result: Other diagnostic escape mutations found in the surface ORF were sR122K (5.9%), sG145A (5.9%), and sW172* (5.9%).

Discussion: Further sequence analysis revealed other mutations such as sR122K, sG145A andsW172* within the surface ORF of the OBI subjects (mainly belonging to HBV/D1 and D3) but at low frequencies.

Discussion: The presence of both sR122K and s

Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China.

PMID: 28600703 2017 Archives of virology

Abstract: Furthermore, the mutations sY100C, sQ101R/K, sS114A, sP120T, sT/I126A/N/S, sQ129R, sM133L/T/S and sG145R/A were prevalent in at least one genotype, with a frequency higher than 1%, which indicated that these mutations were relatively common.

Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.

PMID: 28751727 2017 Scientific reports

Abstract: The hottest mutation position was aa126 (I126S/N and T126A, 29.63%), and aa 145 (G145R/A, 25.93%).

Introduction: G145R mutation was the first identified VEMs to be described in 1990, and later several other notable VEMs (I/T126S, Q129H, G130N, D144A, G145A) at different positions associated with HBV breakthrough infections have also been repeatedly documented worldwide.

Result: Eight types of these mutations (I126S, I126N, Q129H, S143L,

Molecular evolution of hepatitis B vaccine escape variants in China, during 2000-2016.

PMID: 28939157 2017 Vaccine

Abstract: Four sites (A5T/S, L21S, T/A126S and T/N131I/A) and 13 sites (N3S, T5A, G10Q/R/E, L21S, T47K/A/V, L98V/P, I/S126N/V/T, Q129H/R/L, T131P/I/N/A, G145A/R, L175S/F, L213I/S, V224A/G) were found to be under positive selection in genotype B and C HBV vaccine escape strains, re

Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger.

PMID: 26899956 2016 International journal of infectious diseases

Abstract: Amino acid substitutions found in HBV sequences obtained here included P120T, S143L, G145A and A194T.

Impact of Universal Hepatitis B Vaccination on Prevalence, Infection-Associated Morbidity and Mortality, and Circulation of Immune Escape Variants in Russia.

PMID: 27280884 2016 PloS one

Table: G145R/A

Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.

PMID: 27882062 2016 Hepatitis monthly

Discussion: Avellon reported M133T (2.2%), Q129H, M133I, F/Y134N (1.8%), F/Y134L, G145A (1.5%), and P120T (1.1%) as the most frequent mutations of S region, while G145R was found at a frequency of less than 1% (0.4%), while among them just Q129H was found in the current study.

Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.

PMID: 27882070 2016 Hepatitis monthly

Result: The well-known G145A/R variant was not observed.

Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt.

PMID: 26420301 2015 Virology journal

Result: The well-known G145A/R variant was not observed in either the overt infection or occult infection group.

Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.

PMID: 26457811 2015 PloS one

Abstract: The surface gene from the child and his father had the same amino acid substitution pattern (T118K, T123N and G145A).

Result: All of the nine clones from the son have the same amino acid substitution pattern (T118K, T123N and G145A) as seen in his father.

Result: Amino acid substitutions in the major hydrophilic region predicted from nine clones of HBV from the son's sample include L104S, T118K, T123N, S143L and G145A.

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