literature

HBV mutation literature information.

[HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment].

PMID: 31130119 2019 Mikrobiyoloji bulteni

Abstract: Because of the HBV pol/S gene overlapping, in 27 patients immun-selected amino acid substitutions (sI110L, sT127P, sS114A, sT123A), in nine patients HBIg selected escape mutants (sP120R, sT123N, sE164D, sY134F, sQ129H, sT118A,

Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.

PMID: 31880877 2019 Polish journal of microbiology

Result: The mutation patterns were sI110L + sS193L, sP120L + + sT123N + sT126I + sA128V + sY134H + sD144E + +sG145A, sT118A+sP127T, sI110L+

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

PMID: 29859062 2018 BMC infectious diseases

Method: Among them, sP120S/T/A, sT126N/S, sQ129R/N, sT131I/N, sM133I/L, sP142S, sD144A/E, sG145A/R were known to act as vaccine-escape mutations.

Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R,

PMID: 30080852 2018 PLoS neglected tropical diseases

Table: G145A/R

Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.

PMID: 30584239 2018 Scientific reports

Result: Amino acid substitutions associated with immune escape, such as sT118K (n = 3), sG145A (n = 3), and sG145R (n = 1) variants, were abundant, especially in non-HSCT patients at HBV reactivation.

Result: Finally, more than 99% of all the circulating HBV isolates became sG145A variants, followed by a subsequent decrease in the viral load mediated by administration of the nucleoside analogue entecavir.

Result: Of note, the frequency of sG145A variants, representing immune escape variants, increased from 0% to 86.1% for the total viral population in accordance with

Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.

PMID: 28582431 2017 PloS one

Result: A total of 22 strains had mutations only within E2; S143L (n = 11), S143SL (n = 3), D144A (n = 1), D144E (n = 2), D144DG (n = 1), G145A (n = 2), and G145GR (n = 2).

Result: Three strains had mutations within E2 plus additional mutations outside of E1 and E2; S143SL, T131TN, and M133MT (n = 1), D144A, G145A, and M133I (n = 1), and G145R, T126TI, and Y134YN (n = 1).

The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients.

PMID: 27422771 2017 Journal of gastroenterology

Abstract: Two HBV re-infected patients without HCC recurrence had HBs gene mutations G145R and G145A, respectively.

Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

PMID: 28332361 2017 Yonsei medical journal

Discussion: The 'a' determinant mutations found in this study were I126M/N, P127S/T, T131N, S132F, M133T, F134L/T, D144E, and G145A.

Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.

PMID: 28045894 2017 PloS one

Discussion: Glycine-to-alanine at 145 (G145A) and glutamine-to-arginine at 129 (Q129R) mutations were also found in the HBs amino acids sequence isolated from separate infants who already received recombinant hepatitis B vaccine.

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (

Browser Board

Co-occurred Entities

Filtrator