literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: G130R

Molecular characterization of hepatitis B virus in blood donors in Botswana.

PMID: 30382563 2019 Virus genes

Abstract: The escape mutations sP120L, sG130R, sY134H, and sD144A were identified predominantly among HBV isolates from blood donors.

Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N,

Molecular and serological characterization of occult hepatitis B virus infection among patients with hemophilia.

PMID: 30908666 2019 Journal of medical virology

Abstract: sR73H, sI110L, sP120A, sP127T, sQ129H, sG130R, and sC137S were shown to be the most determinant escape mutation and OBI-relevant mutants.

Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.

PMID: 29604477 2018 Virology

Discussion: Of the other immune escape mutants with severely impaired virion secretion, I110M, G145R, and K141E mutants showed mild to moderate reduction in HBsAg secretion, while G119V, G130R, and C147R mutants had more or less WT efficiency of HBsAg secretion.

Discussion: The M133T mutation could efficiently rescue virion secretion of the I110M, T118K, G119E, P127S, G145R, and R169H mutants to nearly WT level, and moderately improve virion secretion of the

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

PMID: 29859062 2018 BMC infectious diseases

Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, sP127L, sA128V, sQ129R/N, sG130N/R, sT131I, sM133I/L/T,

Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.

PMID: 28582431 2017 PloS one

Result: Finally 15 strains had mutations outside of E1 and E2; Y100C plus Q129R (n = 1), L109LR (n = 1), T126S (n = 1), T126TS (n = 1), A128V (n = 1), Q129H (n = 1), Q129QH (n = 1), G130R (n = 1), G130R, T131N and M133T (n = 1), T131N (n = 1), T131TN (n = 1), T131I (n = 1), T133TLMS (n = 1), Y134S (n = 1), and Y134YN (n = 1).

Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.

PMID: 24835494 2014 PloS one

Table: G130S/R

A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

PMID: 22720022 2012 PloS one

Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1), T131I (n = 4), M133L/T (n = 18), G144E (n = 1) and G145A/R (n = 4).

Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.

PMID: 20382061 2010 International journal of infectious diseases

Abstract: In the NUC therapy group the prevalence was 8.5% (12/142), with the following patterns: sY100C+sI110V, sL109I, sP120T, sP127T, sG130R+sG145X, sS132A+sY134N, sY134N+sG145R, s

A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.

PMID: 20492719 2010 Virology journal

Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.

Result: C121Y(TGC TAC), T126S/T126A(ACT TCT or ACT GCT), Q129K(CAA AAA), G130R(GGA AGA), G145R(GGA AGA) and other aa substitution compared with consensus sequence in MHR were also showed in figure 2.

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