Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Method: Mutations creating novel N-linked glycosylation, such as 112NG113, 114NT115, T115N, and G130N, were introduced to the 0.7mer construct b
Result: The M133T mutation was most efficient at rescuing virion secretion of the G145R mutant, followed by G115N and G130N.
Result: To characterize their biological properties, we generated 0.7mer expression construct containing T115N, G130N, 112NG113 (insertion of the NG dipeptide between residues 112 and 113.
Discussion: In the current work we also performed limited study on four additional mutants creating novel N-linked glycosylation sites: T115N, G130N, 112NG113, and 114NT115.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L,
Discussion: Finally, among our ten HBV sequenced strains, we found only one strain with a G130N mutation like VEM as described, and associated with diagnostic failure, rarely described (1%).
Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.
Introduction: G145R mutation was the first identified VEMs to be described in 1990, and later several other notable VEMs (I/T126S, Q129H, G130N, D144A, G145A) at different positions associated with HBV breakthrough infections have also been repeatedly documented worldwide.
Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs.
PMID: 26613893
2016
The Brazilian journal of infectious diseases
1Abstract: Mutation sI126S/T within the ""a"" determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity."
Modification of Asparagine-Linked Glycan Density for the Design of Hepatitis B Virus Virus-Like Particles with Enhanced Immunogenicity.
Discussion: The MHR region contains residues 99-169 of HBsAg and T/I126S, Q129H, G130N, S143L, D144A, G145A, and G145R were among the commonly reported mutations.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
HBV mutation literature information.
PMID: 
2018
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