Discussion: Several specific mutations, including G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R, have been reported as being related to the decrease of HBsAg secretion.
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
8Discussion: reported that major hydrophilic region (MHR) mutations in the ""a"" determinant region (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) can significantly decrease virion, HBsAg detection and apparent occult HBV infection."
Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.
Abstract: Mutations in the S region of HBV DNA included S114T, G119R, P120S, T125M, C139Y, T140I, C147W, T148A, A159V/G, E164D, V168A, and R169C.
Result: Variants were found in 30.4% (21/69) of cases with OBI and included S114T, G119R, P120S, T125M, C139Y, T140I,
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The major population of MHR variants causing impaired of HBsAg secretion (e.g., G119R, Q129R, T140I, and G145R) was detected only in advanced liver disease patients.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
Discussion: Thirteen MHR mutations (G119R, P120T, C124R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, G145A, and G145R) were detected and functionally characterized in vitro and in vivo.
HBV mutation literature information.
PMID: 
2020
International journal of medical sciences
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