Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen.
Abstract: Recently, a phenylalanine (F)-to-leucine (L) mutation at this position (mutant F97L) in HBV surface antigen subtype ayw has been shown to result in an immature secretion phenotype, which is characterized by the nonselective export of an excessive amount of virions containing minus-strand, single-stranded HBV DNA.
Abstract: While subtype ayw mutant F97L has been found in Europe, the major reservoir of HBV resides in Asia and Africa.
HBV mutation literature information.
PMID: 
1999
Journal of virology
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