literature

HBV mutation literature information.

Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.

PMID: 33562603 2021 International journal of molecular sciences

Discussion: One study showed that the F501L substitution exhibited a decreased pregenomic RNA encapsidation level, resulting in defective DNA synthesis.

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective.

PMID: 9462667 1998 Hepatology (Baltimore, Md.)

1Abstract: In addition, other mutations in the reverse-transcriptase ""B domain"" involving either a phenylalanine (F)-to-leucine (L) at amino acid 501 (F501L) or an L-to-M substitution at amino acid 515 (L515M) have been observed during 3TC and Famciclovir therapy as well."

Abstract: Double mutants with the L515M substitution showed intermediate defect between the YI/VDD or F501L and the L515M single-mutant strains.

Abstract: In both HCC and HEK 293 cells, the mutant viruses carrying the F501L substitution showed a decreased pregenomic RNA encapsidation level, suggesting that the defect in HBV DNA synthesis occ

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