Result: Only F141V/L/I was found with a significantly higher rate in the HCC group (18.4% vs 9.6%, p = 0.08).
Result: The point-mutations with the rates of over 30% were T125S/N/P (30.8%), I150T (42.5%), and V158A (36%); from 10 to <30% of population were M120V/I (11.3%) and F141V/L/I (11.3%); and from 5 to <10% of population were Q121R/K (5.3%), T164I/D/S (6.1%), and F165S/L (5.7%).
Table: F141V/L
Discussion: Only F141V/L/I had the higher distributi
rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Result: F141L in PreS2 has been reported to be significantly related to HCC progression in Korean chronic patients by inducing cell cycle progression by downregulating the p53 and p21 pathways and upregulating CDK4 and cyclin A.
Discussion: Indeed, we found several rt269I signature mutation types related to lower HBV replication (I84T/M/L/V in PreS1, preC-W28Stop, V/L5M in X region, C-I97F/L in C region and rtM204I/V
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Introduction: The pre-S2 mutation F141L and the pre-S1 mutation W182*, leading to the premature termination of HBsAg, are reportedly associated with more severe HBV infection (Mun et al.,; Lee et al.,).
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Discussion: Additionally, the F141L mutation in the PreS region was not found in any of the HIV/HBV co-infected individuals, although this mutation was found to be significant among the liver cirrhosis patients compared to the chronic HBV cases with HBV mono-infection.
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Introduction: The two types of mutations related to clinical severity, the F141L preS2 mutation and W182* leading to premature termination in the HBV surface antigen (HBsAg), were recently noted in Korean chronic patients.
Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections.
Abstract: By studying stable cell lines, we found that F141L-LHBs could induce cell cycle progression by downregulating the p53 and p21 pathways and upregulating CDK4 and cyclin A.
Abstract: Furthermore, we found that in a colony-forming assay, the colony-forming rates in cell lines expressing F141L-LHBs were about twice as high as those of the wild type.
Abstract: Here, we describe a novel HCC-related pre-S2 mutation, F141L.
Abstract: In conclusion, our results suggest that F141L-LHBs may contribute importantly to the pathogenesis of HCC by inducing cell proliferation and transfor
Clonal analysis of hepatitis B viruses among blood donors from Joinville, Brazil: evidence of dual infections, intragenotype recombination and markers of risk for hepatocellular carcinoma.
HBV mutation literature information.
PMID: 
2022
PloS one
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