Discussion: Multivariate logistic regression analysis was informative as it confirmed our finding that H
Discussion: Several previous studies on HBV genotypes have reported that H94Y, I127T, K130M, V131I, and F132Y/I/R mutations are frequently considered as associated risk factors of HCC and may promote progression of liver impairment.
Discussion: The prevalence of I127T, V131I, and F132Y/I/R mutations showed an increasing trend with increase in severity of disease from the IC to the HCC group.
HBx mutations promote hepatoma cell migration through the Wnt/beta-catenin signaling pathway.
Introduction: 127 (isoleucine to asparagine/serine/threonine), 130 (lysine to methionine), 131 (valine to isoleucine), and 132 (phenylalanine to tyrosine), which might affect the biological activity of HBx.18, 19 However, the potential role of HBx Combo mutations in hepatocarcinogenesis is largely unknown.
Discussion: substitutions (I127N/K130M/V131I/F132Y) that may lead to aberrant biological activity of HBx.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Discussion: Moreover, T1768A result in aa changes at HBx codon 132 (F132Y), that have been showed to play a synergetic role with K130M and V131I introduced by A1762T/G1764A for leading to carcinogenesis.
Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.
Method: In addition, a combination mutant of I127N/K130M/V131/I/F132Y (abbreviated as Combo mutant) was generated.
Discussion: Our results in HepG2 and Huh7cells indicate that Combo mutant HBx I127N/K130M/V131/I/F132Y with changes corresponding to core promoter mutations T1753A/A1762T/G1764A/T1768A that are typically found in patients close to the time of diagnosis of HCC decreased p21 expression while TA double mutation or o
Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.
PMID: 19439550
2009
The Journal of general virology
Abstract: Due to a compact viral genome organization, BCP1 and BCP2 mutations result in amino acids changes in the overlapping X gene: K130M/V131I and F132Y, respectively.
"Biological impacts of ""hot-spot"" mutations of hepatitis B virus X proteins are genotype B and C differentiated."
PMID: 16094714
2005
World journal of gastroenterology
Abstract: RESULTS: As compared to standard genotype B HBx, mutants of I127T and I127T+K130M+V131I showed higher transactivation and anti-proliferative activities, while the mutants of F132Y, K130M+V131I, and K130M+V131I+F132Y showed lower activities.
Abstract: With regard to anti-proliferative activity, compared to standard genotype C HBx, F132Y and K130M+ V131I mutants showed lower activities, and K130M+
Mutations in the transcriptional regulatory region of the precore and core/pregenome of a hepatitis B virus with defective HBeAg production.
Abstract: The deduced amino acid substitutions were 28 Arg--Gln, 94 His--Tyr, 131 Val--Ile and 132 Phe--Tyr of HBx and 715 Met--Val and 789 Asp--Asn of pol.
HBV mutation literature information.
PMID: 
2017
Oncotarget
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