Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
PMID: 35415256
2022
Clinical and experimental hepatology
Introduction: In a study conducted in the Korean population, the five HBcAg mutations P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop were significantly more frequent in subjects with chronic hepatitis and cirrhosis.
Naturally occurring core protein mutations compensate for the reduced replication fitness of a lamivudine-resistant HBV isolate.
Method: The PCR fragment containing the combined 6 core mutations (P5T/S35T/P79Q/E83D/S87G/Q177K) were amplified from pCMVHBV-GYF-L97I and the PCR product was used as primers to mutate pCMVHBV-WT by Q5 mutagenesis, giving rise to plasmid pCMVHBV-WT-6Cmut.
Result: Furthermore, introducing I97L mutation into WT did not enhance viral DNA replication, but changing WT core to other six mutations together (P5T, S35T, P79Q, E83D, S87G, and Q177K) signif
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Introduction: Furthermore, five HBcAg mutations identified in a Korean population, P5H/L/T, E83D, I97F/L, L100I, and Q182K/Stop, were shown to be significantly enriched in HCC patients compared with patients at earlier disease stages, including those with cirrhosis and chronic hepatitis (Kim et al.,).
Table: E83D
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Abstract: Six (preC-W28*, C-P5H/L/T, C-E83D, C-I97F/L, C-L100I and C-Q182K/*) and seven types (preC-W28*, preC-G29D, C-D32N/H, C-E43K, C-P50A/H/Y, C- PMID: 21569538
2011
Virology journal
Introduction: A336C/A336T/T337C variations in HBV core gene, destroying the cleavage sites of Tsp509I, were demonstrated to correlate with the decreases in serum HBV DNA levels and HBV replication in chronic hepatitis B patients, and moreover, A336C/A336T variations caused the substitution of Glu-83 with Asp in HBcAg.
Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B.
Abstract: 5 SNPs, A261T, A336C, A336T T337C and T385C, were found to be associated with RFLP patterns change and only SNP A336C or A336T caused the substitution of Glu-83 with Asp in HBcAg.
Abstract: The serum HBV DNA level in RFLP pattern C was higher than that in RFLP pattern G and C/G mixture, respectively, most possibly which associating with aminoacid change, Glu83Asp.
HBV mutation literature information.
PMID: 
2022
Clinical and experimental hepatology
Browser Board
Co-occurred Entities
Filtrator
ViMRT