Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
PMID: 35415256
2022
Clinical and experimental hepatology
Discussion: The present study also demonstrated that the rates of F24Y, E64D, E77Q, L116I, and
Discussion: There were some variations such as E77Q, E113Q, S181P/H and Q182K/*Stop outside of the epitope regions which have previously been reported to accumulate with disease progression.
Discussion: They also found that F24Y, E64D, and V91S/T mutations were located in the T-cell epitope regions, and E77Q, A80I/T/V, and L116I were located within the B-cell epitope regions.
The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Abstract: Two precore mutations, W28* and G29D, and six core mutations, F24Y, E64D, E77Q, A80I/T/V, L116I, and E180A were significantly associated with the development of cirrhosis and HCC.
Discussion: Some of these mutations, such as E77Q, A80I/V, and L116I, are present at multiple stages of HBV infection, whereas others are associated with a specific clinical stage.
Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Result: A polyclonal rabbit antibody (Dako) efficiently detects the wild-type core protein, but it is less reactive with the core protein of clone 4B due to an E77Q mutation (Kim K et al., unpublished).
HBV mutation literature information.
PMID: 
2022
Clinical and experimental hepatology
Browser Board
Co-occurred Entities
Filtrator
ViMRT