Discussion: All these results suggested that E2G/A induce the HBsAg intracellular accumulation, which might be related to its secretion impairment.
Discussion: Another interesting novel finding from the present study was that N-terminal signal peptides were exclusively detected in S proteins with secretion-defective mutants mentioned previously (E2G/A) (Supplementary Figure 2).
Discussion: First of all, further studies will be needed to elucidate the different mechanisms of OBI genotype B and genotype C caused by E2G.
Discussion: In the present study, beside the S protein mutation E2G in OBI genotype B we previously reported, a sig
Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
Abstract: E2G might cause HBsAg secretion impairment that results in intracellular accumulation and a decrease in HBsAg secretion.
Abstract: Five of the ten mutations (E2G, D144E, G145R, V168A and S174N) strongly decreased extracellular HBsAg level (P < .05) in the transfection system.
Abstract: Hence, ten mutations were associated with genotype B occult HBV infection; E2G and V168A were novel mutations which we confirmed significantly affect HBsAg detection.
Abstract: Notably, the E2G
Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.
Abstract: Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region.
Result: Amino acid substitutions of sE2G (n = 3), sL77R (n = 1), and sL98V (n = 1) in the small S protein that were associated with impaired virion secretion were also the pr
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Result: Based on the ELISA and Western blot results, sE2G, sC69*, sL95W, sl98V and sG145R appeared to express significantly decreased HBsAg levels.
Result: we conclude that mutants sE2G, sL95W and sL98V might negatively influence HBV virion secretion and mutants sC69* and sG145R may influence HBV replication.
HBV mutation literature information.
PMID: 
2021
Frontiers in microbiology
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