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 HBV mutation literature information.


  Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B.
 PMID: 21784687       2011       International journal of infectious diseases
Abstract: RESULTS: Seven types of ADAPVEM were detected in the total CHB patients: rtM204V/sI195M, rtM204I/sW196S, rtM204I/sW196L, rtV173L/sE164D, rtA181T/sW172*, rtA181T/


  Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiency virus/hepatitis B virus co-infected patients in Brazil.
 PMID: 20944991       2010       Memorias do Instituto Oswaldo Cruz
Abstract: In 10 patients with viremia, LAM-resistance mutations in the polymerase gene (rtL180M + rtM204V and rtV173L + rtL180M + rtM204V) were found, accompanied by changes in the envelope gene (sI195M, sW196L and sI195M/sE164D).


  High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.
 PMID: 20648600       2010       Journal of medical virology
Abstract: Three patients with the triple polymerase substitution pattern (rtV173L + rtL180M + rtM204V) had associated changes in the envelope gene (sE164D + sI195M).


  Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
 PMID: 20119580       2010       Journal of Korean medical science
Discussion: The LMV-resistant polymerase mutation, rtV173L (sE164D), has been reported to reduce the antigenicity of HBsAg.


  Effect of HIV co-infection on mutation patterns of HBV in patients with lamivudine-resistant chronic hepatitis B.
 PMID: 19475624       2009       Journal of medical virology
Abstract: All patients with the triple mutational pattern showed sE164D + sI195M changes in the envelope gene.


  Efficacy of hepatitis B vaccine against antiviral drug-resistant hepatitis B virus mutants in the chimpanzee model.
 PMID: 19274751       2009       Hepatology (Baltimore, Md.)
Abstract: The polymerase gene mutant contained a combination of three mutations (rtV173L, rtL180M, rtM204V), two of which resulted in changes to the overlapping viral envelope of the hepatitis B surface antigen (sE164D, sI195M).


  Occult hepatitis B virus infection in HIV-infected patients: Evaluation of biochemical, virological and molecular parameters.
 PMID: 18624719       2008       Hepatology research
Abstract: In the second patient, E164D and I195M substitutions in HBsAg, associated with lamivudine-resistance mutations in the polymerase were identified.


  Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant.
 PMID: 18572757       2008       Antiviral therapy
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Abstract: RESULTS: The mutations rtF166L/sF158Y (lamivudine-associated, compensatory) and rtl169T/sF161L (entecavir-associated, primary) acting alone, and the mutations rtV173L/sE164D (lamivudine-associated, compensatory) and rtSilent/sD144E (antibody escape-associated) each when combined with rtM204V/sl195M (lamivudine-associated, primary) led to decreases in antibody reactivity to epitopes in the first or second loop, or in both loops.


  Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil.
 PMID: 18211717       2008       BMC microbiology
Discussion: The triple mutation rtV173L/rtL180M/rtM204V/I results in concomitant amino acid substitutions E164D and I195M in the small S protein.


  Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine.
 PMID: 15339340       2004       BMC infectious diseases
Discussion: The triple mutation V519L, L526M, M550V causes the concomitant amino acid substitutions E164D and I195M in the small S protein.



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