literature

HBV mutation literature information.

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Abstract: Genetic sequencing of HBV showed the mutants of S143T, D144G, and G145R in the S gene region, and the mutant of site 1896 in the

Result: Mutation analysis of this patient's HBV showed there were three mutants (S143T, D144G, and G145R) in the S gene region, and the mutant of site 1896 in the pre-Core region coexisted with the wild type (G1896A/G), but no mutation in the pre-S1, pre-S2, and BCP gene regions (Details shown in Table 3).

Table: D144G

Occult and active hepatitis B virus detection in donated blood in Sao Paulo, Brazil.

PMID: 33687074 2021 Transfusion

Abstract: Among them, T123N, G145A, and D144G high-impact immune escape mutations were identified.

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, M204I/V, L217R, L229V/

Figure: T118X represents T118A/R/V; M133X represents M133I/L/T; Q129X represents Q129A/R; D144X represents D144A/E/G/N.

Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.

PMID: 31682960 2020 International journal of infectious diseases

Discussion: Many studies (Protzer-Knolle et al.,; Beckebaum et al.,; Cheung et al.,) have demonstrated that M133T itself is frequently associated with occult HBV infection and is also often associated with some mutations in the 'a' determinant such as G130N, F134L, D144A, D144G, G145A, G145K, and G145R or failed hepatitis B immune globulin (HBIG) prophylaxis.

Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.

PMID: 29604477 2018 Virology

Discussion: In the present study, we demonstrated its ability to moderately rescue virion secretion of the T114R, T115A, K141E, and D144G mut

Discussion: Indeed, with the Abbott Architect i2000 assay, the K141E, D144G, and G145R escape mutants as well as M133T glycosylation mutant were associated with very little HBsAg in culture supernatant.

Discussion: Similarly, Western blot analysis revealed very little intracellular S protein for the K141E, D144G, G145R, and M133T mutants (panel A in Figs.

A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.

PMID: 30080852 2018 PLoS neglected tropical diseases

Result: sD144A/E/G occurring in genotype A (6/69, 8.7%), D (10/69, 14.5%) and E (7/69, 10.1%) associated with VEM.

Molecular epidemiology of co-infection with hepatitis B virus and human immunodeficiency virus (HIV) among adult patients in Harare, Zimbabwe.

PMID: 27458715 2017 Journal of medical virology

Abstract: PreS deletion mutants and small S antigen variants M133I/T and D144G were identified.

Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.

PMID: 29016603 2017 PloS one

Discussion: In Latin America, the escape mutant D144A/G was characterized in a vaccinated child and potential escape mutants were identified in HBsAg+/anti-HBs+ patients in Argentina.

Discussion: Moreover, there are other reported escape mutants (P120T, T126A/S, and D144A/G) responsible for the evasion of vaccine-induced antibodies and therefore cause HBV infection in vaccinated individuals.

Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.

PMID: 25320728 2014 Clinical and molecular hepatology

Discussion: A mixture of D144G/D144A or combined D144E / G145R mutations were detected after hepatitis B immune globulin treatment.

Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants.

PMID: 23296324 2013 Human vaccines & immunotherapeutics

Abstract: HBsAg resulted undetectable by 3 of the 8 samples, derived from patients with multiple mutations: T126I-T131A-C139Y-E/D144G, T126I-M133L, and P120Q-T126I.

Browser Board

Co-occurred Entities

Filtrator