literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: D144E/A

[Identification by enzyme immunoassay of escape mutants S143L and G145R of hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus)].

PMID: 35293188 2022 Voprosy virusologii

Abstract: CONCLUSION: ELISA-based detection of escape mutations S143L, D144E and G145R can be used for routine diagnostics, especially in the risk groups.

Abstract: The presence of neighbor mutation D144E can be assumed due to it special serological fingerprint.

Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.

PMID: 35271684 2022 PloS one

Result: Seven amino acid substitutions were detected in HBsAg of strains isolated from pregnant women, including the conversion of Ile Leu at amino acid 110 (I110L), Thr Pro at amino acid 127 (T127P), Asp Glu at amino acid 144 (D144E), Ser Ala at amino acid 154 (S154A), Gly Ala at amino acid 159 (G159A), Ala Gly at amino acid 166 (A166G) and Ala Val at amino acid 168 (A168V) of HBsAg (S1 Fig and Table 2).

Table:

Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.

PMID: 34234472 2021 Infection and drug resistance

Abstract: The observed mutations were T115S (3/20, 15%), P120T/S (3/20, 15%), T126S (1/20, 5%), Q129R (2/20, 10%), M133T (2/20, 10%), S143L (5/20, 25%), D144E/A (3/20, 15%), and G145R/A (4/20, 20%).

Result: The following mutation pairs were observed: T115S (3/20, 15%), P120T/S (3/20, 15%), T126S (1/20, 5%), Q129R (2/20, 10%), M133T (2/20, 10%), S143L (5/20, 25%), D144E/A (3/20, 15%), and G145R/A

Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.

PMID: 34210073 2021 Viruses

Introduction: In the following years, other mutations observed on the a-determinant, which are considered as immune escape variants, including T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, P142S, and D144A/E, have also been reported.

Discussion: All sequences obtained in this study were classified as HBV genotype E, which is known to show a clear genotypic divergence from all genotypes within the a determinant, where escape mutations can occur, reported that the types of polymorphisms at positions associated with escape mutations observed in HBV vary from one genotype to another and that the most common of these

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).

Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V,

PMID: 32922195 2020 International journal of medical sciences

1Abstract: By sequencing analysis, we revealed mutations at the ""a"" determinant of HBsAg, including Q129R, T131N, M133S, F134L and D144E."

5Result: However, patient No.6 was found to have mutations of Gln129Arg (Q129R), Thr131Asn (T131N), Met133Ser (M133S), Phe134Leu (F134L) and Asp144Glu (D144E) in the ""a"" determinant of HBsAg (Figure 2, Table 3)."

Discussion: The presence of

Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.

PMID: 32336003 2020 Journal of viral hepatitis

Abstract: Five of the ten mutations (E2G, D144E, G145R, V168A and S174N) strongly decreased extracellular HBsAg level (P < .05) in the transfection system.

Abstract: Ten occult infection-related mutations (E2G, Q101R, K122R, M133T, D144E, G145R, V168A, S174N, L175S and I226S) were significantly more frequent in the occult infection group (P < .05).

The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients.

PMID: 32763811 2020 Journal of clinical virology

Abstract: Strains with sK122R mutants (sK122R, sK122R + D144E, sK122R + C121R + D144E, and sK122R + F134L + D144E) from a follow-up OBI patient all showed significantly lower levels of HBsAg production than a wild-type strain.

A recombinant human immunoglobulin with coherent avidity to hepatitis B virus surface antigens of various viral genotypes and clinical mutants.

PMID: 32790777 2020 PloS one

Result: D144A and D144E also shared this feature.

Result: In contrast, the polyclonal anti-HBsAg antibody signal was severely reduced in several mutants within the 2nd loop of 'a' determinant, such as K141I, P142L/S, D144A/E, G145K/R, N146S and T148I.

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