literature

HBV mutation literature information.

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Table: D144A

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.

PMID: 29434654 2018 Infectious agents and cancer

Discussion: Several specific mutations, including G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R, have been reported as being related to the decrease of HBsAg secretion.

Quasispecies characters of hepatitis B virus in immunoprophylaxis failure infants.

PMID: 29629487 2018 European journal of clinical microbiology & infectious diseases

Abstract: In our data, the substitution rate of amino acid located at a determinant is relatively low (< 10%), I/T126A, C124S, F134Y, K141Q, Q129H, D144A, G145V, and N146K, which showed no statistical difference to their mothers, proving that these vaccine escape mutants preexist maternally as minor variants.

A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.

PMID: 30080852 2018 PLoS neglected tropical diseases

Result: sD144A/E/G occurring in genotype A (6/69, 8.7%), D (10/69, 14.5%) and E (7/69, 10.1%) associated with VEM.

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, s Result: Vaccine escape mutations were found in 7 (11.1%) patients including 040N (sG145R), 159N (sQ129H), 007N (sQ129R), 054N (sD144A), 127E (sD144E), 006N (sD144E), and 119E (sD144E).

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.

PMID: 27650283 2017 Journal of hepatology

8Discussion: reported that major hydrophilic region (MHR) mutations in the ""a"" determinant region (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) can significantly decrease virion, HBsAg detection and apparent occult HBV infection."

Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.

PMID: 29016603 2017 PloS one

Discussion: In Latin America, the escape mutant D144A/G was characterized in a vaccinated child and potential escape mutants were identified in HBsAg+/anti-HBs+ patients in Argentina.

Discussion: Moreover, there are other reported escape mutants (P120T, T126A/S, and D144A/G) responsible for the evasion of vaccine-induced antibodies and therefore cause HBV infection in vaccinated individuals.

Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.

PMID: 28582431 2017 PloS one

Result: A total of 22 strains had mutations only within E2; S143L (n = 11), S143SL (n = 3), D144A (n = 1), D144E (n = 2), D144DG (n = 1), G145A (n = 2), and G145GR (n = 2).

Result: Three strains had mutations within E2 plus additional mutations outside of E1 and E2; S143SL, T131TN, and M133MT (n = 1), D144A, G145A, and M133I (n = 1), and G145R, T126TI, and Y134YN (n = 1).

Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.

PMID: 28751727 2017 Scientific reports

Result: Among 9 mutated isolates sharing 6 types of aa substitutions with HBV genotype B, three types of VEMs (T126A, Q129H and D144A) were also detected (Table 4).

Result: Eight types of these mutations (I126S, I126N, Q129H, S143L, D144A, D144E, G145A, and G145R) had demonstrated low ability to bind antibodies and were identified as VEMs previously.

Table: D144A

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